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6iol

From Proteopedia

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(New page: '''Unreleased structure''' The entry 6iol is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (10:34, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6iol is ON HOLD
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==Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state)==
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<SX load='6iol' size='340' side='right' viewer='molstar' caption='[[6iol]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6iol]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IOL FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.76&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iol OCA], [https://pdbe.org/6iol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iol RCSB], [https://www.ebi.ac.uk/pdbsum/6iol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iol ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MEXA_PSEAE MEXA_PSEAE] The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref> The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Nakagawa A]]
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[[Category: Tsutsumi K]]
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[[Category: Yamashita E]]
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[[Category: Yonehara R]]

Current revision

Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state)

6iol, resolution 3.76Å

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