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5zz6

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==Redox-sensing transcriptional repressor Rex==
==Redox-sensing transcriptional repressor Rex==
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<StructureSection load='5zz6' size='340' side='right' caption='[[5zz6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5zz6' size='340' side='right'caption='[[5zz6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zz6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZZ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zz6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZZ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zz6 OCA], [http://pdbe.org/5zz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zz6 RCSB], [http://www.ebi.ac.uk/pdbsum/5zz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zz6 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zz6 OCA], [https://pdbe.org/5zz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zz6 RCSB], [https://www.ebi.ac.uk/pdbsum/5zz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zz6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/REX1_THEMA REX1_THEMA]] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
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[https://www.uniprot.org/uniprot/REX1_THEMA REX1_THEMA] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cellular redox state of organisms continues to fluctuate during the metabolism. All organisms have various sensors that help detect and adapt to changes in the redox state. Nicotinamide adenine dinucleotides (NAD(+)/NADH), which are involved in various cellular metabolic activities as cofactors, have been revealed as the key molecules sensing the intra-cellular redox state. The Rex family members are well conserved transcriptional repressors that regulate the expression of respiratory genes by sensing the redox state according to the intra-cellular NAD(+)/NADH balance. Herein, we reported crystal structures of apo and NAD(+)- and NADH-bound forms of Rex from Thermotoga maritima to analyse the structural basis of transcriptional regulation depending on either NAD(+) or NADH binding. The different orientation of the reduced nicotinamide group to helix alpha9 caused the rearrangement of N-terminal DNA binding domain, thus resulting in closed form of Rex to dissociate from cognate DNA. The structural data of Rex from T. maritima also support the previous redox-sensing mechanism models of Rex homologues.
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Structural Analysis of Redox-sensing Transcriptional Repressor Rex from Thermotoga maritima.,Park YW, Jang YY, Joo HK, Lee JY Sci Rep. 2018 Sep 5;8(1):13244. doi: 10.1038/s41598-018-31676-z. PMID:30185822<ref>PMID:30185822</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5zz6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Jang, Y Y]]
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[[Category: Large Structures]]
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[[Category: Joo, H K]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Lee, J Y]]
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[[Category: Jang YY]]
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[[Category: Park, Y W]]
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[[Category: Joo HK]]
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[[Category: Gene regulation]]
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[[Category: Lee JY]]
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[[Category: Redox sensing]]
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[[Category: Park YW]]
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[[Category: Transcription factor]]
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Current revision

Redox-sensing transcriptional repressor Rex

PDB ID 5zz6

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