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6al2

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==Crystal structure of a Membrane protein insertase==
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==Crystal structure of E. coli YidC at 2.8 A resolution==
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<StructureSection load='6al2' size='340' side='right' caption='[[6al2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='6al2' size='340' side='right'caption='[[6al2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6al2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AL2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6al2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AL2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6al2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al2 OCA], [http://pdbe.org/6al2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6al2 RCSB], [http://www.ebi.ac.uk/pdbsum/6al2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6al2 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6al2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al2 OCA], [https://pdbe.org/6al2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6al2 RCSB], [https://www.ebi.ac.uk/pdbsum/6al2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6al2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/YIDC_ECO45 YIDC_ECO45]] Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
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[https://www.uniprot.org/uniprot/YIDC_ECOLI YIDC_ECOLI] Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F(0)ATP synthase, FtsQ and SecE proteins and for Sec-independent subunit c of the F(0)ATP synthase, M13 phage procoat and the N-terminus of leader peptidase Lep. Probably interacts directly with Sec-independent substrates. Sec-dependent protein FtsQ interacts first with SecY then subsequently with YidC. Sec-dependent LacY and MalF require YidC to acquire tertiary structure and stability, a chaperone-like function, but not for membrane insertion. Stable maltose transport copmplex formation (MalFGK(2)) also requires YidC. Partially complements a Streptococcus mutans yidC2 disruption mutant.<ref>PMID:10675323</ref> <ref>PMID:10949305</ref> <ref>PMID:12724529</ref> <ref>PMID:12950181</ref> <ref>PMID:15140892</ref> <ref>PMID:15067017</ref> <ref>PMID:17073462</ref> <ref>PMID:18456666</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6al2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6al2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Insertase|Insertase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fujii, A]]
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[[Category: Escherichia coli]]
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[[Category: Hamid, A A]]
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[[Category: Large Structures]]
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[[Category: Izumioka, A]]
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[[Category: Fujii A]]
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[[Category: Tanaka, Y]]
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[[Category: Hamid AA]]
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[[Category: Tsukazaki, T]]
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[[Category: Izumioka A]]
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[[Category: Chaperone]]
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[[Category: Tanaka Y]]
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[[Category: Insertase]]
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[[Category: Tsukazaki T]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of E. coli YidC at 2.8 A resolution

PDB ID 6al2

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