This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ciy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:29, 30 August 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA==
==Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA==
-
<StructureSection load='3ciy' size='340' side='right' caption='[[3ciy]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
+
<StructureSection load='3ciy' size='340' side='right'caption='[[3ciy]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3ciy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. The November 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CIY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3ciy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The November 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CIY FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cig|3cig]], [[2a0z|2a0z]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tlr3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ciy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ciy OCA], [https://pdbe.org/3ciy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ciy RCSB], [https://www.ebi.ac.uk/pdbsum/3ciy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ciy ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ciy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ciy OCA], [http://pdbe.org/3ciy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ciy RCSB], [http://www.ebi.ac.uk/pdbsum/3ciy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ciy ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TLR3_MOUSE TLR3_MOUSE]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:14993594</ref>
+
[https://www.uniprot.org/uniprot/TLR3_MOUSE TLR3_MOUSE] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:14993594</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 33: Line 32:
==See Also==
==See Also==
*[[Leucine-rich repeat|Leucine-rich repeat]]
*[[Leucine-rich repeat|Leucine-rich repeat]]
 +
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
*[[Toll-like Receptors|Toll-like Receptors]]
*[[Toll-like Receptors|Toll-like Receptors]]
-
*[[User:Wayne Decatur/NASCE2011|User:Wayne Decatur/NASCE2011]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Lk3 transgenic mice]]
+
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Toll-like Receptors]]
[[Category: Toll-like Receptors]]
-
[[Category: Botos, I]]
+
[[Category: Botos I]]
-
[[Category: Davies, D R]]
+
[[Category: Davies DR]]
-
[[Category: Leonard, J N]]
+
[[Category: Leonard JN]]
-
[[Category: Liu, L]]
+
[[Category: Liu L]]
-
[[Category: Segal, D M]]
+
[[Category: Segal DM]]
-
[[Category: Shiloach, J]]
+
[[Category: Shiloach J]]
-
[[Category: Wang, Y]]
+
[[Category: Wang Y]]
-
[[Category: Dsrna]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Immune response]]
+
-
[[Category: Immune system-rna complex]]
+
-
[[Category: Inflammatory response]]
+
-
[[Category: Innate immunity]]
+
-
[[Category: Leucine rich repeat]]
+
-
[[Category: Leucine-rich repeat]]
+
-
[[Category: Lrr]]
+
-
[[Category: Membrane]]
+
-
[[Category: Protein-dsrna complex]]
+
-
[[Category: Receptor]]
+
-
[[Category: Tlr]]
+
-
[[Category: Transmembrane]]
+

Current revision

Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA

PDB ID 3ciy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ciy"
Personal tools