Sialidase

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(Redirecting to Neuraminidase)
 
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<StructureSection load='3h72' size='340' side='right' caption='Sialidase complex with sialic acid (PDB code [[3h72]])' scene=''>
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#REDIRECT [[Neuraminidase]]
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== Function ==
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'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. The sialic acid-binding domain of sialidase is called CBD. For '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate. For '''Trans-sialidase''' see [[Neuraminidase]].
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== Structural highlights ==
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Sialidase active site interactions of sialidase with sialic acid include salt bridges, hydrogen bonds and polar interactions<ref>PMID:19284989</ref>.
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</StructureSection>
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==3D structures of salidase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Salidase
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**[[1eur]] - MvNANA residues 43-407 – ''Micromonospora viridifaciens''<br />
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**[[1euu]] - MvNANA residues 47-647<br />
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**[[1wcq]], [[1w8n]], [[1w8o]], [[2hu0]], [[2hu4]] – MvNANA residues 47-647 (mutant) <br />
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**[[5mqr]], [[5mqs]], [[4bbw]], [[5muk]], [[5mul]] - BtSal - ''Bacterioides thetaiotaomicron'' <br />
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** [[1mz5]], [[1n1s]] - TrSal - ''Trypanosoma rangeli''<br />
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** [[1wcs]] - TrSal (mutant) <br />
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**[[3sil]] – StSal (mutant) – ''Salmonella typhimurium''<br />
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**[[1snt]], [[1so7]] – hSal2 - human<br />
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**[[2f24]], [[2f26]], [[2f28]] – hSal2 (mutant) <br />
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**[[2w20]] – SpSal A catalytic domain - ''Streptococcus pneumoniae''<br />
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**[[4zxk]] – SpSal A CBD <br />
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**[[2vw0]], [[2vw2]], [[4xik]], [[2ya4]], [[2w20]], [[2vvz]], [[3h71]] - SpSal B<br />
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** [[4xmi]], [[4xio]], [[4xj8]], [[4xma]], [[4xjz]], [[4xik]] - SpSal B (mutant) <br />
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**[[4yw4]] – SpSal C <br />
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**[[2xzi]], [[2xzj]], [[2xzk]], [[2xcy]] – AfSal – ''Aspergillus fumigatus''<br />
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** [[4m4n]], [[4m4u]] - AfSal (mutant) <br />
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**[[1sll]] – Sal L - leech<br />
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**[[2vk5]], [[5tsp]] - CpSal I – ''Clostridium perfringens''<br />
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*Salidase complexes
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**[[2w68]] – VcSal CBD + sialic acid – ''Vibrio cholerae''<br />
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**[[1kit]]– VcSal + sialic acid <br />
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**[[1w0p]] – VcSal + sialic acid derivative<br />
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**[[6eks]], [[6eku]] – VcSal + drug<br />
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**[[3h72]], [[2ya5]] – SpSal A + sialic acid <br />
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**[[4c1w]], [[4c1x]] – SpSal A CBD + sialic acid derivative<br />
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**[[2ya7]], [[2ya8]], [[5kky]], [[5f9t]], [[2ya6]], [[2jkb]] - SpSal A catalytic domain + drug<br />
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**[[2vvz]], [[3h73]] – SpSal A + neuraminic acid derivative <br />
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**[[2vw1]] – SpSal B + neuraminic acid derivative <br />
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**[[4xyx]] – SpSal B + drug<br />
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**[[4xog]], [[4xjw]], [[4xj9]], [[4xil]], [[4xe9]] – SpSal B (mutant) + drug<br />
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**[[4foq]], [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]] – SpSal B + inhibitor<br />
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**[[4xju]], [[4xja]], [[4xhx]], [[4xhb]] – SpSal B (mutant) + inhibitor<br />
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**[[2jkb]] – SpSal B + sialic acid derivative<br />
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**[[4yz3]], [[4yw5]] – SpSal C + drug<br />
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**[[4yw2]] – SpSal C + sialic acid <br />
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**[[4yz4]], [[4yz2]] – SpSal C + neuraminic acid derivative <br />
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**[[4yw1]], [[4yw3]] – SpSal C + sialic acid + neuraminic acid derivative<br />
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**[[1w0o]] – VcSal + sialic acid + neuraminic acid derivative<br />
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**[[2vk6]], [[2vk7]] – CpSal I + neuraminic acid derivative <br />
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**[[2bf6]] – CpSal I residues 243-691 + sialic acid <br />
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**[[5fra]], [[5fre]] – CpSal I CBD + sialic acid <br />
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**[[2v73]]– CpSal J CBD + sialic acid <br />
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**[[2v72]]– CpSal J CBD + galactose <br />
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**[[1n1v]] – TrSal + neuraminic acid derivative <br />
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**[[1mz6]], [[1n1t]], [[2ags]] – TrSal + inhibitor <br />
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**[[1n1y]] – TrSal + sialic acid <br />
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**[[2a75]], [[2fhr]] – TrSal + sialic acid derivative<br />
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**[[1dim]], [[1dil]], [[2sil]], [[2sim]] – StSal + inhibitor <br />
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**[[1eus]] - MvSal residues 43-407 + neuraminic acid derivative<br />
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**[[1eut]] - MvSal residues 47-647 + galactose<br />
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**[[2bzd]] - MvSal residues 47-647 (mutant) + galactose<br />
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**[[1w80]] - MvSal residues 47-647 (mutant) + lactose<br />
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**[[1wcq]], [[1w8n]] – MvSal (mutant) + neuraminic acid derivative<br />
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**[[2ber]] – MvSal (mutant) + sialic acid derivative<br />
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**[[4m4v]] – AfSal (mutant) + neuraminic acid derivative<br />
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**[[1vcu]], [[2f0z]], [[2f10]], [[2f11]], [[2f12]], [[2f13]] - hSal2 + inhibitor<br />
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**[[2f25]], [[2f27]], [[2f29]], [[4nc5]], [[4ncs]] - hSal2 (mutant) + inhibitor<br />
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**[[5mul]] – BtSal + glucuronic acid<br />
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*Anhydrosialidase
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**[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br />
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**[[4x49]] - RgSal + tamiflu<br />
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**[[4x6k]] - RgSal + siastatin<br />
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}}
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== References ==
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<references/>
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[[Category:Topic Page]]
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Current revision

  1. REDIRECT Neuraminidase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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