This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Pseudouridine synthase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(better specify there are two types of complexes among the pseudouridine synthases)
Current revision (09:20, 5 December 2019) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA and pseudouridine monophosphate [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
+
<StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
-
== Function ==
+
__TOC__
-
[[Pseudouridine]] is an abundant modified nucleotide found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the base of uridine. There are two major types of enzymes that catalyze this reaction:
+
==Function==
 +
[[Pseudouridine]] is an abundant modified nucleoside found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the bond between base and ribose in uridine. There are two major types of enzymes that catalyze this reaction:
-
* [[RNA-guided Pseudoridine synthase] -- ]Complexes of proteins and small RNAs have been identified in archaea and eukaryotes to catalyze these reactions. The small RNA in the complex serves as a guide element to specify the site of modification through base-pairing with the target RNA molecule.
+
* [[RNA-guided pseudouridine synthase]] -- Some ribonucleoproteins (complexes of proteins and small RNAs) have been identified in archaea and eukaryotes to catalyze these reactions. The small RNA in the complex serves as a guide element to select the site of modification through base-pairing with the target RNA molecule.
-
* [[Guide-independent Pseudouridine synthase]] -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a [[Guide-independent Pseudouridine synthase|guide-independent mechanism]] acting through stand-alone enzymes to catalyze formation.
+
* [[Guide-independent Pseudouridine synthase|Guide-independent pseudouridine synthase]] -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a [[Guide-independent Pseudouridine synthase|guide-independent mechanism]] acting through protein-only enzymes to catalyze the isomerization.
== Structural highlights ==
== Structural highlights ==
-
The conversion of uridine to pseudouridine causes conformational change of PUS<ref>PMID:14990747</ref>. <scene name='46/465439/Cv/3'>tRNA pseudouridine synthase binding with pseudouridine monophosphate</scene> ([[1ze2]]).
+
The conversion of uridine to pseudouridine is accompanied by a conformational change of pseudouridine synthase<ref>PMID:14990747</ref>. <scene name='46/465439/Cv/4'>tRNA pseudouridine synthase binding with pseudouridine monophosphate</scene> ([[1ze2]]).
 +
== 3D Structures of pseudouridine synthase ==
 +
[[Pseudouridine synthase 3D structures]]
 +
 
</StructureSection>
</StructureSection>
 +
 +
 +
[[Category:Topic Page]]

Current revision

tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate 1ze2

Drag the structure with the mouse to rotate
Retrieved from "http://52.214.119.220/wiki/index.php/Pseudouridine_synthase"
Personal tools