RNA-guided pseudouridine synthase

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<StructureSection load='3hay' size='400' side='right' caption=' 'Pyrococcus furiosus RNA-guided Pseudouridine synthase in complex with substrate [[3hay]]' scene='' pspeed='8'>
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<StructureSection load='3hay' size='400' side='right' caption='Pyrococcus furiosus RNA-guided Pseudouridine synthase (grey) in complex with small nucleolarRNP Gar-like protein (green), ribosome biogenesis protein Nop10 (pink), 50S ribosomal protein L7AE (yellow), RNA, pseudouridine derivative and Zn+2 ion (grey) (PDB code [[3hay]])' scene='' pspeed='8'>
== Function ==
== Function ==
H/ACA ribonucleoproteins that use RNAs to guide [[pseudouridine|pseudouridine]] formation.
H/ACA ribonucleoproteins that use RNAs to guide [[pseudouridine|pseudouridine]] formation.
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==Structures of RNA-guided pseudoridine synthase==
==Structures of RNA-guided pseudoridine synthase==
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Eukaryotic
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* Eukaryotic
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* [[Cbf5-Nop10-Gar1]] complex (eukaryote Saccharomyces cerevisiae]]
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** [[3u28]] Cbf5-Nop10-Gar1 complex (''Saccharomyces cerevisiae'')
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Archaeal
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* Archaeal
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** [[3hay]] - the full complex with substrate RNA ( ''Pyrococcus furiosus'')
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** [[3hay]] - the full complex with substrate RNA (''Pyrococcus furiosus'')
** [[3hjw]] - the Cbf5-L7Ae-Nop10-guide RNA-substrate RNA complex (''Pyrococcus furiosus'')
** [[3hjw]] - the Cbf5-L7Ae-Nop10-guide RNA-substrate RNA complex (''Pyrococcus furiosus'')
** [[2hvy]] - Cbf5-Gar1-L7Ae-Nop10-guide RNA complex (''Pyrococcus furiosus'')
** [[2hvy]] - Cbf5-Gar1-L7Ae-Nop10-guide RNA complex (''Pyrococcus furiosus'')

Current revision

Pyrococcus furiosus RNA-guided Pseudouridine synthase (grey) in complex with small nucleolarRNP Gar-like protein (green), ribosome biogenesis protein Nop10 (pink), 50S ribosomal protein L7AE (yellow), RNA, pseudouridine derivative and Zn+2 ion (grey) (PDB code 3hay)

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Wayne Decatur, Michal Harel, Angel Herraez

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