6i2y

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'''Unreleased structure'''
 
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The entry 6i2y is ON HOLD
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==Human STK10 bound to Foretinib==
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<StructureSection load='6i2y' size='340' side='right'caption='[[6i2y]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6i2y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I2Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=88Z:N-(3-FLUORO-4-{[6-METHOXY-7-(3-MORPHOLIN-4-YLPROPOXY)QUINOLIN-4-YL]OXY}PHENYL)-N-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE'>88Z</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i2y OCA], [https://pdbe.org/6i2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i2y RCSB], [https://www.ebi.ac.uk/pdbsum/6i2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i2y ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
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Authors: Sorrell, F.J., Berger, B.-T., Oerum, S., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Elkins, J.M.
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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Description: Human STK10 bound to Foretinib
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Oerum, S]]
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__TOC__
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[[Category: Elkins, J.M]]
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</StructureSection>
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[[Category: Berger, B.-T]]
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[[Category: Homo sapiens]]
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[[Category: Von Delft, F]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Knapp, S]]
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[[Category: Berger B-T]]
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[[Category: Edwards, A.M]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Edwards AM]]
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[[Category: Sorrell, F.J]]
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[[Category: Elkins JM]]
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[[Category: Knapp S]]
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[[Category: Oerum S]]
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[[Category: Sorrell FJ]]
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[[Category: Von Delft F]]

Current revision

Human STK10 bound to Foretinib

PDB ID 6i2y

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