6n04
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6n04 is ON HOLD Authors: Clinger, J.A., Wang, X., Cai, W., Miller, M.D., Van Lanen, S.G., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Na...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The X-ray crystal structure of AbsH3, an FAD dependent reductase from the Abyssomicin biosynthesis pathway in Streptomyces== |
| + | <StructureSection load='6n04' size='340' side='right'caption='[[6n04]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n04]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._LC-6-2 Streptomyces sp. LC-6-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N04 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.998Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n04 OCA], [https://pdbe.org/6n04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n04 RCSB], [https://www.ebi.ac.uk/pdbsum/6n04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n04 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1V0QH64_9ACTN A0A1V0QH64_9ACTN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Natural products and natural product-derived compounds have been widely used for pharmaceuticals for many years, and the search for new natural products that may have interesting activity is ongoing. Abyssomicins are natural product molecules that have antibiotic activity via inhibition of the folate synthesis pathway in microbiota. These compounds also appear to undergo a required [4 + 2] cycloaddition in their biosynthetic pathway. Here we report the structure of an flavin adenine dinucleotide-dependent reductase, AbsH3, from the biosynthetic gene cluster of novel abyssomicins found in Streptomyces sp. LC-6-2. | ||
| - | + | The crystal structure of AbsH3: A putative flavin adenine dinucleotide-dependent reductase in the abyssomicin biosynthesis pathway.,Clinger JA, Wang X, Cai W, Zhu Y, Miller MD, Zhan CG, Van Lanen SG, Thorson JS, Phillips GN Jr Proteins. 2020 Aug 27. doi: 10.1002/prot.25994. PMID:32852843<ref>PMID:32852843</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 6n04" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Clinger | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Phillips Jr]] | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Streptomyces sp. LC-6-2]] |
| - | [[Category: | + | [[Category: Cai W]] |
| - | [[Category: Wang | + | [[Category: Clinger JA]] |
| + | [[Category: Miller MD]] | ||
| + | [[Category: Phillips Jr GN]] | ||
| + | [[Category: Thorson JS]] | ||
| + | [[Category: Van Lanen SG]] | ||
| + | [[Category: Wang X]] | ||
Current revision
The X-ray crystal structure of AbsH3, an FAD dependent reductase from the Abyssomicin biosynthesis pathway in Streptomyces
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