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6n1i
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6n1i is ON HOLD Authors: Li, Y., Fu, T., Wu, H. Description: Cryo-EM structure of NLRC4-CARD filament Category: Unreleased Structures [[Categor...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of NLRC4-CARD filament== | |
| - | + | <SX load='6n1i' size='340' side='right' viewer='molstar' caption='[[6n1i]], [[Resolution|resolution]] 3.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n1i]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6drp 6drp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N1I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.58Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n1i OCA], [https://pdbe.org/6n1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n1i RCSB], [https://www.ebi.ac.uk/pdbsum/6n1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n1i ProSAT]</span></td></tr> |
| - | [[Category: Fu | + | </table> |
| - | [[Category: Li | + | == Disease == |
| - | [[Category: Wu | + | [https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]<ref>PMID:15107016</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fu T]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Wu H]] | ||
Current revision
Cryo-EM structure of NLRC4-CARD filament
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Categories: Homo sapiens | Large Structures | Fu T | Li Y | Wu H
