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2via

From Proteopedia

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[[Image:2via.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of S172AbsSHMT L-Serine external aldimine==
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|PDB= 2via |SIZE=350|CAPTION= <scene name='initialview01'>2via</scene>, resolution 1.67&Aring;
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<StructureSection load='2via' size='340' side='right'caption='[[2via]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Plp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:SER+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mpd+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Mpd+Binding+Site+For+Chain+A'>AC4</scene> and <scene name='pdbsite=AC5:Po4+Binding+Site+For+Chain+A'>AC5</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>
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<table><tr><td colspan='2'>[[2via]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VIA FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2via OCA], [https://pdbe.org/2via PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2via RCSB], [https://www.ebi.ac.uk/pdbsum/2via PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2via ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2vgu|2VGU]], [[1yjy|1YJY]], [[2vi9|2VI9]], [[1yjs|1YJS]], [[1kl2|1KL2]], [[2vi8|2VI8]], [[1kl1|1KL1]], [[1kkp|1KKP]], [[2vgs|2VGS]], [[1yjz|1YJZ]], [[2vgt|2VGT]], [[2vgv|2VGV]], [[1kkj|1KKJ]], [[2vgw|2VGW]], [[2vib|2VIB]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2via OCA], [http://www.ebi.ac.uk/pdbsum/2via PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2via RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2via_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2via ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF S172ABSSHMT L-SERINE EXTERNAL ALDIMINE'''
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==See Also==
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*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2VIA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIA OCA].
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[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Glycine hydroxymethyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Appaji Rao N]]
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[[Category: Bhavani, B S.]]
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[[Category: Bhavani BS]]
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[[Category: Murthy, M R.N.]]
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[[Category: Murthy MRN]]
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[[Category: Prakash, V.]]
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[[Category: Prakash V]]
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[[Category: Rajaram, V.]]
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[[Category: Rajaram V]]
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[[Category: Rao, N Appaji.]]
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[[Category: Savithri HS]]
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[[Category: Savithri, H S.]]
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[[Category: e53q]]
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[[Category: enzyme memory]]
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[[Category: fthf]]
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[[Category: one-carbon metabolism]]
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[[Category: plp-dependent enzyme]]
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[[Category: pyridoxal phosphate]]
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[[Category: shmt]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:12:37 2008''
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Current revision

Crystal structure of S172AbsSHMT L-Serine external aldimine

PDB ID 2via

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