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3d4u

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==Bovine thrombin-activatable fibrinolysis inhibitor (TAFIa) in complex with tick-derived carboxypeptidase inhibitor.==
==Bovine thrombin-activatable fibrinolysis inhibitor (TAFIa) in complex with tick-derived carboxypeptidase inhibitor.==
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<StructureSection load='3d4u' size='340' side='right' caption='[[3d4u]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3d4u' size='340' side='right'caption='[[3d4u]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3d4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rhibu Rhibu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D4U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3d4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rhipicephalus_bursa Rhipicephalus bursa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D4U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zli|1zli]], [[1kwm|1kwm]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_U Carboxypeptidase U], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.20 3.4.17.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d4u OCA], [https://pdbe.org/3d4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d4u RCSB], [https://www.ebi.ac.uk/pdbsum/3d4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d4u ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d4u OCA], [http://pdbe.org/3d4u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d4u RCSB], [http://www.ebi.ac.uk/pdbsum/3d4u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d4u ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBPB2_BOVIN CBPB2_BOVIN]] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
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[https://www.uniprot.org/uniprot/CBPB2_BOVIN CBPB2_BOVIN] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Carboxypeptidase|Carboxypeptidase]]
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*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Carboxypeptidase U]]
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[[Category: Large Structures]]
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[[Category: Rhibu]]
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[[Category: Rhipicephalus bursa]]
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[[Category: Arolas, J L]]
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[[Category: Arolas JL]]
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[[Category: Aviles, F X]]
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[[Category: Aviles FX]]
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[[Category: Enghild, J J]]
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[[Category: Enghild JJ]]
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[[Category: Gomis-Ruth, F X]]
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[[Category: Gomis-Ruth FX]]
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[[Category: Guevara, T]]
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[[Category: Guevara T]]
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[[Category: Kristensen, T]]
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[[Category: Kristensen T]]
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[[Category: Pallares, I]]
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[[Category: Pallares I]]
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[[Category: Sanglas, L]]
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[[Category: Sanglas L]]
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[[Category: Sola, M]]
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[[Category: Sola M]]
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[[Category: Valnickova, Z]]
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[[Category: Valnickova Z]]
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[[Category: Blood coagulation]]
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[[Category: Carboxypeptidase]]
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[[Category: Fibrinolysis]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Metal-binding]]
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[[Category: Metalloenzyme inhibitor]]
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[[Category: Metalloprotease]]
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[[Category: Metalloprotease inhibitor]]
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[[Category: Protease]]
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[[Category: Protease-inhibitor complex]]
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[[Category: Secreted]]
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[[Category: Zymogen]]
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Current revision

Bovine thrombin-activatable fibrinolysis inhibitor (TAFIa) in complex with tick-derived carboxypeptidase inhibitor.

PDB ID 3d4u

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