This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3dzi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:55, 30 August 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex==
==Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex==
-
<StructureSection load='3dzi' size='340' side='right' caption='[[3dzi]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
+
<StructureSection load='3dzi' size='340' side='right'caption='[[3dzi]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3dzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DZI FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3dzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DZI FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene>, <scene name='pdbligand=RGT:2-AMINO-9-{5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-RIBOFURANOSYL}-9H-PURIN-6-YL+5-O-PHOSPHONO-BETA-D-RIBOFURANOSIDE'>RGT</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dzf|3dzf]], [[3dzg|3dzg]], [[3dzh|3dzh]], [[3dzj|3dzj]], [[3dzk|3dzk]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene>, <scene name='pdbligand=RGT:2-AMINO-9-{5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-RIBOFURANOSYL}-9H-PURIN-6-YL+5-O-PHOSPHONO-BETA-D-RIBOFURANOSIDE'>RGT</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dzi OCA], [https://pdbe.org/3dzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dzi RCSB], [https://www.ebi.ac.uk/pdbsum/3dzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dzi ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dzi OCA], [http://pdbe.org/3dzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dzi RCSB], [http://www.ebi.ac.uk/pdbsum/3dzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dzi ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
+
[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 38: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Graeff, R]]
+
[[Category: Large Structures]]
-
[[Category: Hao, Q]]
+
[[Category: Graeff R]]
-
[[Category: Jiang, H]]
+
[[Category: Hao Q]]
-
[[Category: Kriksunov, I A]]
+
[[Category: Jiang H]]
-
[[Category: Lee, H C]]
+
[[Category: Kriksunov IA]]
-
[[Category: Lin, H]]
+
[[Category: Lee HC]]
-
[[Category: Liu, Q]]
+
[[Category: Lin H]]
-
[[Category: Alpha bundle]]
+
[[Category: Liu Q]]
-
[[Category: Alternative splicing]]
+
-
[[Category: Beta sheet]]
+
-
[[Category: Diabetes mellitus]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Gtp complex]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Membrane]]
+
-
[[Category: Nad]]
+
-
[[Category: Noncovalent intermediate]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: R5p-gtp adduct]]
+
-
[[Category: Receptor]]
+
-
[[Category: Signal-anchor]]
+
-
[[Category: Transmembrane]]
+

Current revision

Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex

PDB ID 3dzi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3dzi"
Personal tools