This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2vpi
From Proteopedia
(Difference between revisions)
| (12 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2vpi.jpg|left|200px]] | ||
| - | + | ==Human GMP synthetase - glutaminase domain== | |
| - | + | <StructureSection load='2vpi' size='340' side='right'caption='[[2vpi]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2vpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpi OCA], [https://pdbe.org/2vpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpi RCSB], [https://www.ebi.ac.uk/pdbsum/2vpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpi ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | | | + | == Disease == |
| - | | | + | [https://www.uniprot.org/uniprot/GUAA_HUMAN GUAA_HUMAN] A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1. |
| - | + | == Function == | |
| + | [https://www.uniprot.org/uniprot/GUAA_HUMAN GUAA_HUMAN] Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.<ref>PMID:8089153</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpi_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vpi ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[GMP synthase|GMP synthase]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | + | [[Category: Berglund H]] | |
| - | [[Category: Berglund | + | [[Category: Busam RD]] |
| - | [[Category: Busam | + | [[Category: Collins R]] |
| - | [[Category: Collins | + | [[Category: Dahlgren LG]] |
| - | [[Category: Dahlgren | + | [[Category: Edwards AM]] |
| - | [[Category: Edwards | + | [[Category: Flodin S]] |
| - | [[Category: Flodin | + | [[Category: Flores A]] |
| - | [[Category: Flores | + | [[Category: Graslund S]] |
| - | [[Category: Graslund | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hammarstrom | + | [[Category: Herman MD]] |
| - | [[Category: Herman | + | [[Category: Johansson I]] |
| - | [[Category: Johansson | + | [[Category: Kallas A]] |
| - | [[Category: Kallas | + | [[Category: Karlberg T]] |
| - | [[Category: Karlberg | + | [[Category: Kotenyova T]] |
| - | [[Category: Kotenyova | + | [[Category: Lehtio L]] |
| - | [[Category: Lehtio | + | [[Category: Moche M]] |
| - | [[Category: Moche | + | [[Category: Nilsson ME]] |
| - | [[Category: Nilsson | + | [[Category: Nordlund P]] |
| - | [[Category: Nordlund | + | [[Category: Nyman T]] |
| - | [[Category: Nyman | + | [[Category: Persson C]] |
| - | [[Category: Persson | + | [[Category: Sagemark J]] |
| - | [[Category: Sagemark | + | [[Category: Svensson L]] |
| - | + | [[Category: Thorsell AG]] | |
| - | [[Category: Svensson | + | [[Category: Tresaugues L]] |
| - | [[Category: Thorsell | + | [[Category: Van Der Berg S]] |
| - | [[Category: Tresaugues | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Welin M]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Human GMP synthetase - glutaminase domain
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Busam RD | Collins R | Dahlgren LG | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Herman MD | Johansson I | Kallas A | Karlberg T | Kotenyova T | Lehtio L | Moche M | Nilsson ME | Nordlund P | Nyman T | Persson C | Sagemark J | Svensson L | Thorsell AG | Tresaugues L | Van Der Berg S | Weigelt J | Welin M
