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Colony-stimulating factor

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<StructureSection load='4wrl' size='340' side='right' caption='Glycosylated human macrophage colony-stimulating factor (pink and yellow) complex with macrophage colony-stimulating factor 1 receptor (grey and green) (PDB code [[4wrl]])' scene=''>
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<StructureSection load='4wrl' size='340' side='right' caption='Glycosylated human macrophage colony-stimulating factor (deeppink and salmon) complex with macrophage colony-stimulating factor 1 receptor (deepskyblue and green) (PDB code [[4wrl]])' scene='80/801266/Cv/1'>
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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The structure of the complex between M-CSF and its receptor shows that a dimer of M-CSF binds to 2 molecules of the receptor. There are two binding sites between the molecules designated site I and site II<ref>PMID:26235028</ref>.
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The structure of the complex between M-CSF and its receptor shows that a <scene name='80/801266/Cv/3'>dimer of M-CSF binds to 2 molecules of the receptor</scene>. There are <scene name='80/801266/Cv/5'>two binding sites between the molecules designated site I and site II</scene><ref>PMID:26235028</ref>. <scene name='80/801266/Cv/4'>All interactions</scene>. See also [[Colony-stimulating factor receptor]]
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</StructureSection>
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==3D structures of colony-stimulating factor==
==3D structures of colony-stimulating factor==
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[[Colony-stimulating factor 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Macrophage colony stimulating factor
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**[[2gmf]], [[3uf2]] - hM-CSF - human<br />
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**[[5lxf]] - hM-CSF (mutant)<br />
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**[[4adq]], [[4adf]] - hM-CSF + BARF1<br />
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**[[3uez]] - hM-CSF (mutant) + BARF1<br />
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**[[4wrm]], [[4wrl]] - hM-CSF + CSF receptor<br />
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**[[3uf5]] - mM-CSF - mouse<br />
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**[[3ejj]] - mM-CSF + CSF receptor<br />
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*Granulocyte-macrophage colony stimulating factor
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**[[2gmf]], [[1csg]] - hGM-CSF<br />
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**[[5c7x]], [[5d70]], [[5d71]], [[5d72]], [[6bfq]], [[6bfs]] - hGM-CSF + antibody<br />
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**[[4rs1]] - hGM-CSF + CSF receptor<br />
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**[[4nkq]] - hGM-CSF + CSF receptor + cytokine receptor<br />
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**[[5d22]] - sGM-CSF - sheep<br />
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**[[5d28]] - sGM-CSF + CSF inhibition factor<br />
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*Granulocyte colony stimulating factor
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**[[1bgc]] - G-CSF - bovine<br />
 
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**[[1bgd]], [[1bge]] - G-CSF - dog<br />
 
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**[[1rhg]] - hG-CSF <br />
 
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**[[1gnc]] - hG-CSF - NMR<br />
 
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**[[5gw9]] - hG-CSF (mutant)<br />
 
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**[[2d9q]], [[1pgr]], [[1cd9]] - hG-CSF + CSF receptor<br />
 
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**[[1gcf]], [[1cto]] - mG-CSF C-terminal of LBD - NMR<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Glycosylated human macrophage colony-stimulating factor (deeppink and salmon) complex with macrophage colony-stimulating factor 1 receptor (deepskyblue and green) (PDB code 4wrl)

Drag the structure with the mouse to rotate

References

  1. ↑ Nemunaitis J. A comparative review of colony-stimulating factors. Drugs. 1997 Nov;54(5):709-29. doi: 10.2165/00003495-199754050-00004. PMID:9360058 doi:http://dx.doi.org/10.2165/00003495-199754050-00004
  2. ↑ Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 2006 Feb;16(2):126-33. doi: 10.1038/sj.cr.7310017. PMID:16474424 doi:http://dx.doi.org/10.1038/sj.cr.7310017
  3. ↑ Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008 Jul;8(7):533-44. doi: 10.1038/nri2356. PMID:18551128 doi:http://dx.doi.org/10.1038/nri2356
  4. ↑ Metcalf D. The colony-stimulating factors and cancer. Nat Rev Cancer. 2010 Jun;10(6):425-34. doi: 10.1038/nrc2843. PMID:20495576 doi:http://dx.doi.org/10.1038/nrc2843
  5. ↑ Schneider A, Kuhn HG, Schabitz WR. A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system. Cell Cycle. 2005 Dec;4(12):1753-7. doi: 10.4161/cc.4.12.2213. Epub 2005 Dec 27. PMID:16258290 doi:http://dx.doi.org/10.4161/cc.4.12.2213
  6. ↑ Lieschke GJ, Burgess AW. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1). N Engl J Med. 1992 Jul 2;327(1):28-35. doi: 10.1056/NEJM199207023270106. PMID:1375975 doi:http://dx.doi.org/10.1056/NEJM199207023270106
  7. ↑ Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN. Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure. 2015 Jul 21. pii: S0969-2126(15)00272-5. doi:, 10.1016/j.str.2015.06.019. PMID:26235028 doi:http://dx.doi.org/10.1016/j.str.2015.06.019

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