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Synaptosomal-associated protein
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='3hd7' size='340' side='right' caption='RAT neuronal SNARE complex containing SNAP25 N-terminal SNARE motif (gold), SNAP25 C-terminal SNARE motif (red), syntaxin-1a SNARE motif (cyan), VAMP2 SNARE motif (magenta), glycylglycylglycine and sulfate (PDB code [[3hd7]])' scene=''> |
== Function == | == Function == | ||
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== Disease == | == Disease == | ||
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| + | Mutation in SNAP25 induces a severe working memory deficit and some common adulthood psychiatric disorders<ref>PMID:23497716</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | SNAP25 has two SNARE motifs - one at its N-terminal and the other at its C-terminal. These motives make complexes with [[Syntaxin]] and <ref>PMID:18596234</ref>. | + | SNAP25 has two SNARE motifs - one at its N-terminal and the other at its C-terminal. These motives make complexes with [[Syntaxin]] and VAMP2<ref>PMID:18596234</ref>. |
</StructureSection> | </StructureSection> | ||
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**[[6mdo]], [[6dmp]] – rSNAP25 + vesicle fusing ATPase – rat – cryo EM<br /> | **[[6mdo]], [[6dmp]] – rSNAP25 + vesicle fusing ATPase – rat – cryo EM<br /> | ||
| - | **[[3j96]], [[3j97]], [[3j98]], [[3j99]], [[6mdm]], [[6mdn]] – rSNAP25 + vesicle fusing ATPase + VAMP2 + rSyntaxin 1a SNARE motif + | + | **[[3j96]], [[3j97]], [[3j98]], [[3j99]], [[6mdm]], [[6mdn]] – rSNAP25 + vesicle fusing ATPase + VAMP2 + rSyntaxin 1a SNARE motif + α-soluble NSF attachment protein – cryo EM<br /> |
**[[1xtg]] – hSNAP25 C-terminal SNARE motif – human<br /> | **[[1xtg]] – hSNAP25 C-terminal SNARE motif – human<br /> | ||
**[[3dda]], [[3ddb]] – hSNAP25 C-terminal SNARE motif + botulinum neurotoxin<br /> | **[[3dda]], [[3ddb]] – hSNAP25 C-terminal SNARE motif + botulinum neurotoxin<br /> | ||
Current revision
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3D structures of synaptosomal-associated protein
Updated on 29-November-2018
Updated on 29-November-2018 {{#tree:id=OrganizedByTopic|openlevels=0|
References
- ↑ Noor A, Zahid S. A review of the role of synaptosomal-associated protein 25 (SNAP-25) in neurological disorders. Int J Neurosci. 2017 Sep;127(9):805-811. doi: 10.1080/00207454.2016.1248240. Epub, 2016 Nov 1. PMID:27734716 doi:http://dx.doi.org/10.1080/00207454.2016.1248240
- ↑ Ohira K, Kobayashi K, Toyama K, Nakamura HK, Shoji H, Takao K, Takeuchi R, Yamaguchi S, Kataoka M, Otsuka S, Takahashi M, Miyakawa T. Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice. Mol Brain. 2013 Mar 12;6:12. doi: 10.1186/1756-6606-6-12. PMID:23497716 doi:http://dx.doi.org/10.1186/1756-6606-6-12
- ↑ Greber S, Lubec G, Cairns N, Fountoulakis M. Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease. Electrophoresis. 1999 Apr-May;20(4-5):928-34. doi:, 10.1002/(SICI)1522-2683(19990101)20:4/5<928::AID-ELPS928>3.0.CO;2-Z. PMID:10344268 doi:<928::AID-ELPS928>3.0.CO;2-Z http://dx.doi.org/10.1002/(SICI)1522-2683(19990101)20:4/5<928::AID-ELPS928>3.0.CO;2-Z
- ↑ Wang L, Bittner MA, Axelrod D, Holz RW. The structural and functional implications of linked SNARE motifs in SNAP25. Mol Biol Cell. 2008 Sep;19(9):3944-55. doi: 10.1091/mbc.e08-04-0344. Epub 2008, Jul 2. PMID:18596234 doi:http://dx.doi.org/10.1091/mbc.e08-04-0344
