6i6l

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(New page: '''Unreleased structure''' The entry 6i6l is ON HOLD Authors: Cabry, M.P., Offen, W.A., Winzer, T., Li, Y., Graham, I.A., Davies, G.J., Saleh, P. Description: Papaver somniferum O-meth...)
Current revision (11:47, 24 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6i6l is ON HOLD
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==Papaver somniferum O-methyltransferase 1==
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<StructureSection load='6i6l' size='340' side='right'caption='[[6i6l]], [[Resolution|resolution]] 1.29&Aring;' scene=''>
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Authors: Cabry, M.P., Offen, W.A., Winzer, T., Li, Y., Graham, I.A., Davies, G.J., Saleh, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6i6l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I6L FirstGlance]. <br>
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Description: Papaver somniferum O-methyltransferase 1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.29&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H68:Tetrahydrocolumbamine'>H68</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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[[Category: Saleh, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6l OCA], [https://pdbe.org/6i6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i6l RCSB], [https://www.ebi.ac.uk/pdbsum/6i6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6l ProSAT]</span></td></tr>
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[[Category: Winzer, T]]
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</table>
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[[Category: Li, Y]]
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== Function ==
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[[Category: Offen, W.A]]
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[https://www.uniprot.org/uniprot/SOMT1_PAPSO SOMT1_PAPSO] Methyltransferase involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine (PubMed:22535422, PubMed:22653730, PubMed:29610307). Catalyzes the conversion of (S)-scoulerine to (S)-tetrahydrocolumbamine (PubMed:22535422, PubMed:22653730). Can convert (S)-tetrahydrocolumbamine to tetrahydropalmatine (PubMed:22535422). Can convert (S)-norreticuline to (S)-norcodamine (PubMed:22535422). Can convert (S)-reticuline to (S)-codamine (PubMed:22535422). Substrate preference is (S)-scoulerine > (S)-tetrahydrocolumbamine > (S)-norreticuline > (S)-reticuline (PubMed:22535422).<ref>PMID:22535422</ref> <ref>PMID:22653730</ref> <ref>PMID:29610307</ref>
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[[Category: Davies, G.J]]
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== References ==
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[[Category: Graham, I.A]]
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<references/>
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[[Category: Cabry, M.P]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Papaver somniferum]]
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[[Category: Cabry MP]]
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[[Category: Davies GJ]]
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[[Category: Graham IA]]
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[[Category: Li Y]]
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[[Category: Offen WA]]
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[[Category: Saleh P]]
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[[Category: Winzer T]]

Current revision

Papaver somniferum O-methyltransferase 1

PDB ID 6i6l

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