6n1p
From Proteopedia
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(New page: '''Unreleased structure''' The entry 6n1p is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Dihedral oligomeric complex of GyrA N-terminal fragment with DNA, solved by cryoEM in C2 symmetry== | |
| + | <SX load='6n1p' size='340' side='right' viewer='molstar' caption='[[6n1p]], [[Resolution|resolution]] 6.35Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n1p]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Cloning_vector_pBR322 Cloning vector pBR322] and [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_G54 Streptococcus pneumoniae G54]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N1P FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.35Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n1p OCA], [https://pdbe.org/6n1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n1p RCSB], [https://www.ebi.ac.uk/pdbsum/6n1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n1p ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GYRA_STRR6 GYRA_STRR6] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] | ||
| - | + | ==See Also== | |
| - | + | *[[Gyrase 3D Structures|Gyrase 3D Structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </SX> |
| + | [[Category: Cloning vector pBR322]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptococcus pneumoniae G54]] | ||
| + | [[Category: Grant T]] | ||
| + | [[Category: Mondragon A]] | ||
| + | [[Category: Rosenthal PB]] | ||
| + | [[Category: Soczek KM]] | ||
Current revision
Dihedral oligomeric complex of GyrA N-terminal fragment with DNA, solved by cryoEM in C2 symmetry
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