6n1r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Tetrahedral oligomeric complex of GyrA N-terminal fragment, solved by cryoEM in tetrahedral symmetry== | |
| + | <SX load='6n1r' size='340' side='right' viewer='molstar' caption='[[6n1r]], [[Resolution|resolution]] 4.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n1r]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_G54 Streptococcus pneumoniae G54]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N1R FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n1r OCA], [https://pdbe.org/6n1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n1r RCSB], [https://www.ebi.ac.uk/pdbsum/6n1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n1r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GYRA_STRR6 GYRA_STRR6] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] | ||
| - | + | ==See Also== | |
| - | + | *[[Gyrase 3D Structures|Gyrase 3D Structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </SX> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptococcus pneumoniae G54]] | ||
| + | [[Category: Grant T]] | ||
| + | [[Category: Mondragon A]] | ||
| + | [[Category: Rosenthal PB]] | ||
| + | [[Category: Soczek KM]] | ||
Current revision
Tetrahedral oligomeric complex of GyrA N-terminal fragment, solved by cryoEM in tetrahedral symmetry
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