6n5y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the SNX5 PX domain in complex with the CI-MPR (space group P212121 - Form 1)== | |
| + | <StructureSection load='6n5y' size='340' side='right'caption='[[6n5y]], [[Resolution|resolution]] 2.26Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n5y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N5Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n5y OCA], [https://pdbe.org/6n5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n5y RCSB], [https://www.ebi.ac.uk/pdbsum/6n5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n5y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SNX5_HUMAN SNX5_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.<ref>PMID:18854019</ref> <ref>PMID:21048941</ref> [https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Sorting nexin 3D structures|Sorting nexin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Collins | + | __TOC__ |
| - | [[Category: Paul | + | </StructureSection> |
| - | [[Category: Weeratunga | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Collins B]] | ||
| + | [[Category: Paul B]] | ||
| + | [[Category: Weeratunga S]] | ||
Current revision
Crystal structure of the SNX5 PX domain in complex with the CI-MPR (space group P212121 - Form 1)
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