6n5z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the SNX5 PX domain in complex with the Sema4C== | |
| + | <StructureSection load='6n5z' size='340' side='right'caption='[[6n5z]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N5Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n5z OCA], [https://pdbe.org/6n5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n5z RCSB], [https://www.ebi.ac.uk/pdbsum/6n5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n5z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SNX5_HUMAN SNX5_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.<ref>PMID:18854019</ref> <ref>PMID:21048941</ref> [https://www.uniprot.org/uniprot/SEM4C_HUMAN SEM4C_HUMAN] Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.<ref>PMID:17498836</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Sorting nexin 3D structures|Sorting nexin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Collins | + | __TOC__ |
| - | [[Category: Paul | + | </StructureSection> |
| - | [[Category: Weeratunga | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Collins B]] | ||
| + | [[Category: Paul B]] | ||
| + | [[Category: Weeratunga S]] | ||
Current revision
Crystal structure of the SNX5 PX domain in complex with the Sema4C
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