5zhp

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==M3 muscarinic acetylcholine receptor in complex with a selective antagonist==
==M3 muscarinic acetylcholine receptor in complex with a selective antagonist==
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<StructureSection load='5zhp' size='340' side='right' caption='[[5zhp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='5zhp' size='340' side='right'caption='[[5zhp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zhp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZHP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zhp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZHP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9EC:(1R,2R,4S,5S,7s)-7-({[4-fluoro-2-(thiophen-2-yl)phenyl]carbamoyl}oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-9-ium'>9EC</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Chrm3, Chrm-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9EC:(1R,2R,4S,5S,7s)-7-({[4-fluoro-2-(thiophen-2-yl)phenyl]carbamoyl}oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-9-ium'>9EC</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhp OCA], [http://pdbe.org/5zhp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zhp RCSB], [http://www.ebi.ac.uk/pdbsum/5zhp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhp OCA], [https://pdbe.org/5zhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zhp RCSB], [https://www.ebi.ac.uk/pdbsum/5zhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACM3_RAT ACM3_RAT]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<ref>PMID:1527051</ref> <ref>PMID:1657592</ref> <ref>PMID:22358844</ref>
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/ACM3_RAT ACM3_RAT] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<ref>PMID:1527051</ref> <ref>PMID:1657592</ref> <ref>PMID:22358844</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zhp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zhp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Escherichia virus T4]]
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[[Category: Banerjee, A]]
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[[Category: Large Structures]]
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[[Category: Bartuschat, A]]
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[[Category: Rattus norvegicus]]
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[[Category: Clark, M J]]
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[[Category: Banerjee A]]
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[[Category: Eitel, K]]
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[[Category: Bartuschat A]]
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[[Category: Fish, I]]
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[[Category: Clark MJ]]
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[[Category: Fisher, J]]
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[[Category: Eitel K]]
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[[Category: Gmeiner, P]]
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[[Category: Fish I]]
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[[Category: Heinrich, M]]
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[[Category: Fisher J]]
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[[Category: Hirata, K]]
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[[Category: Gmeiner P]]
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[[Category: Hofmann, J]]
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[[Category: Heinrich M]]
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[[Category: Hubner, H]]
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[[Category: Hirata K]]
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[[Category: Kaindl, J]]
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[[Category: Hofmann J]]
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[[Category: Kobilka, B K]]
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[[Category: Hubner H]]
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[[Category: Liu, H]]
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[[Category: Kaindl J]]
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[[Category: Liu, X]]
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[[Category: Kobilka BK]]
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[[Category: Rampp, H]]
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[[Category: Liu H]]
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[[Category: Schaake, B]]
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[[Category: Liu X]]
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[[Category: Shoichet, B K]]
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[[Category: Rampp H]]
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[[Category: Sunahara, R K]]
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[[Category: Schaake B]]
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[[Category: Vincent, S G]]
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[[Category: Shoichet BK]]
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[[Category: G protein coupled receptor]]
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[[Category: Sunahara RK]]
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[[Category: Membrane protein]]
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[[Category: Vincent SG]]

Current revision

M3 muscarinic acetylcholine receptor in complex with a selective antagonist

PDB ID 5zhp

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