2z1c

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[[Image:2z1c.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of HypC from Thermococcus kodakaraensis KOD1==
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|PDB= 2z1c |SIZE=350|CAPTION= <scene name='initialview01'>2z1c</scene>, resolution 1.80&Aring;
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<StructureSection load='2z1c' size='340' side='right'caption='[[2z1c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>
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<table><tr><td colspan='2'>[[2z1c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z1C FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE= hypC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=311400 Thermococcus kodakarensis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z1c OCA], [https://pdbe.org/2z1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z1c RCSB], [https://www.ebi.ac.uk/pdbsum/2z1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z1c ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2z1d|2Z1D]], [[2z1e|2Z1E]], [[2z1f|2Z1F]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z1c OCA], [http://www.ebi.ac.uk/pdbsum/2z1c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z1c RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q5JII0_THEKO Q5JII0_THEKO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/2z1c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z1c ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of HypC from Thermococcus kodakaraensis KOD1'''
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==See Also==
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*[[HypA%2C HypB%2C HypC%2C HypD%2C HypE and HypF 3D structures|HypA%2C HypB%2C HypC%2C HypD%2C HypE and HypF 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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[NiFe] hydrogenase maturation proteins HypC, HypD, and HypE catalyze the insertion and cyanation of the iron center of [NiFe] hydrogenases by an unknown mechanism. We have determined the crystal structures of HypC, HypD, and HypE from Thermococcus kodakaraensis KOD1 at 1.8 A, 2.07 A, and 1.55 A resolution, respectively. The structure of HypD reveals its probable iron binding and active sites for cyanation. An extended conformation of each conserved motif of HypC and HypE allows the essential cysteine residues of both proteins to interact with the active site of HypD. Furthermore, the C-terminal tail of HypE is shown to exist in an ATP-dependent dynamic equilibrium between outward and inward conformations. Unexpectedly, the [4Fe-4S] cluster environment of HypD is quite similar to that of ferredoxin:thioredoxin reductase (FTR), indicating the existence of a redox cascade similar to the FTR system. These results suggest a cyanation reaction mechanism via unique thiol redox signaling in the HypCDE complex.
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[[Category: Large Structures]]
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[[Category: Thermococcus kodakarensis KOD1]]
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==About this Structure==
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[[Category: Arai T]]
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2Z1C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermococcus_kodakarensis Thermococcus kodakarensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1C OCA].
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[[Category: Atomi H]]
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[[Category: Imanaka T]]
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==Reference==
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[[Category: Matsumi R]]
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Crystal structures of [NiFe] hydrogenase maturation proteins HypC, HypD, and HypE: insights into cyanation reaction by thiol redox signaling., Watanabe S, Matsumi R, Arai T, Atomi H, Imanaka T, Miki K, Mol Cell. 2007 Jul 6;27(1):29-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17612488 17612488]
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[[Category: Miki K]]
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[[Category: Single protein]]
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[[Category: Watanabe S]]
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[[Category: Thermococcus kodakarensis]]
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[[Category: Arai, T.]]
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[[Category: Atomi, H.]]
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[[Category: Imanaka, T.]]
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[[Category: Matsumi, R.]]
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[[Category: Miki, K.]]
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[[Category: Watanabe, S.]]
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[[Category: [nife] hydrogenase maturation]]
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[[Category: ob-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:17:21 2008''
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Current revision

Crystal structure of HypC from Thermococcus kodakaraensis KOD1

PDB ID 2z1c

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