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6mg8

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==Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched==
==Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched==
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<StructureSection load='6mg8' size='340' side='right' caption='[[6mg8]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<SX load='6mg8' size='340' side='right' viewer='molstar' caption='[[6mg8]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ptch1, Ptch ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg8 OCA], [http://pdbe.org/6mg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg8 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg8 OCA], [https://pdbe.org/6mg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mg8 RCSB], [https://www.ebi.ac.uk/pdbsum/6mg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTC1_MOUSE PTC1_MOUSE]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
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[https://www.uniprot.org/uniprot/PTC1_MOUSE PTC1_MOUSE] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6mg8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6mg8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Protein patched homolog 1|Protein patched homolog 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Asarnow, D E]]
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[[Category: Mus musculus]]
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[[Category: Beachy, P A]]
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[[Category: Asarnow DE]]
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[[Category: Bulkley, D]]
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[[Category: Beachy PA]]
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[[Category: Cheng, Y]]
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[[Category: Bulkley D]]
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[[Category: Cho, W]]
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[[Category: Cheng Y]]
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[[Category: Myers, B R]]
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[[Category: Cho W]]
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[[Category: Roberts, K J]]
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[[Category: Myers BR]]
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[[Category: Sharma, A]]
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[[Category: Roberts KJ]]
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[[Category: Xin, Y]]
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[[Category: Sharma A]]
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[[Category: Zhang, Y]]
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[[Category: Xin Y]]
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[[Category: Membrane protein]]
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[[Category: Zhang Y]]
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[[Category: Receptor membrane protein]]
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Current revision

Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched

6mg8, resolution 3.60Å

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