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6drh

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Current revision (06:13, 11 October 2023) (edit) (undo)
 
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==ADP-ribosyltransferase toxin/immunity pair==
==ADP-ribosyltransferase toxin/immunity pair==
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<StructureSection load='6drh' size='340' side='right' caption='[[6drh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='6drh' size='340' side='right'caption='[[6drh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6drh]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Serp5 Serp5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6drh]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_proteamaculans_568 Serratia proteamaculans 568]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DRH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.299&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Spro_3018 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=399741 SERP5]), Spro_3017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=399741 SERP5])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-ribosyl-[dinitrogen_reductase]_hydrolase ADP-ribosyl-[dinitrogen reductase] hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.24 3.2.2.24] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6drh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drh OCA], [https://pdbe.org/6drh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6drh RCSB], [https://www.ebi.ac.uk/pdbsum/6drh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6drh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6drh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drh OCA], [http://pdbe.org/6drh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drh RCSB], [http://www.ebi.ac.uk/pdbsum/6drh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drh ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRI1_SERP5 TRI1_SERP5] Immunity component of a contact-dependent interbacterial competition system (also called effector-immunity systems). Acts as an arginine mono-ADP-ribosylhydrolase, mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. De-ADP-ribosylates FtsZ, is able to act on other proteins as well. Neutralizes the toxic activity of cognate toxin Tre1-Sp. Expression of this protein alone in E.coli partially protects the cells against competition by wild-type S.proteamaculans. Neutralizes Tre1-Sp both by occluding its active site via its N-terminal extension and by hydrolyzing the ADP-ribosyl moiety from FtsZ; the 2 activities are dissociable by mutagenesis.<ref>PMID:30343895</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Serp5]]
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[[Category: Large Structures]]
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[[Category: Allaire, M]]
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[[Category: Serratia proteamaculans 568]]
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[[Category: Bosch, D E]]
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[[Category: Allaire M]]
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[[Category: Mougous, J D]]
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[[Category: Bosch DE]]
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[[Category: Ting, S]]
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[[Category: Mougous JD]]
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[[Category: Adp-ribosyltransferase]]
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[[Category: Ting S]]
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[[Category: Immunity]]
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[[Category: Toxin]]
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[[Category: Type vi secretion]]
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Current revision

ADP-ribosyltransferase toxin/immunity pair

PDB ID 6drh

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