This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2z5d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:56, 13 March 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2z5d.gif|left|200px]]
 
-
{{Structure
+
==Human ubiquitin-conjugating enzyme E2 H==
-
|PDB= 2z5d |SIZE=350|CAPTION= <scene name='initialview01'>2z5d</scene>, resolution 2.10&Aring;
+
<StructureSection load='2z5d' size='340' side='right'caption='[[2z5d]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
+
<table><tr><td colspan='2'>[[2z5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yh6 1yh6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5D FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
|GENE= UBE2H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5d OCA], [https://pdbe.org/2z5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5d RCSB], [https://www.ebi.ac.uk/pdbsum/2z5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5d ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5d OCA], [http://www.ebi.ac.uk/pdbsum/2z5d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z5d RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/UBE2H_HUMAN UBE2H_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.<ref>PMID:8132613</ref> <ref>PMID:20061386</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5d_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5d ConSurf].
 +
<div style="clear:both"></div>
-
'''Human ubiquitin-conjugating enzyme E2 H'''
+
==See Also==
-
 
+
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2Z5D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1YH6. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5D OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Ubiquitin--protein ligase]]
+
[[Category: Arrowsmith C]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Battaile KP]]
-
[[Category: Battaile, K P.]]
+
[[Category: Bochkarev A]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Cui H]]
-
[[Category: Cui, H.]]
+
[[Category: Dhe-Paganon S]]
-
[[Category: Dhe-Paganon, S.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Mackenzie F]]
-
[[Category: Mackenzie, F.]]
+
[[Category: Newman EM]]
-
[[Category: Newman, E M.]]
+
[[Category: Sundstrom M]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Walker JR]]
-
[[Category: Sundstrom, M.]]
+
-
[[Category: Walker, J R.]]
+
-
[[Category: ligase]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomic]]
+
-
[[Category: structural genomics consortium]]
+
-
[[Category: ube2h]]
+
-
[[Category: ubiquitin]]
+
-
[[Category: ubiquitin-conjugating enzyme]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:18:44 2008''
+

Current revision

Human ubiquitin-conjugating enzyme E2 H

PDB ID 2z5d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z5d"
Personal tools