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5y49

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'''Unreleased structure'''
 
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The entry 5y49 is ON HOLD until Jan 29 2020
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==A moderator XD22 binding to bile acid receptor==
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<StructureSection load='5y49' size='340' side='right'caption='[[5y49]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5y49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y49 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XD5:[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]+4-azanylbenzoate'>XD5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y49 OCA], [https://pdbe.org/5y49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y49 RCSB], [https://www.ebi.ac.uk/pdbsum/5y49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y49 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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Authors: Lu, Y., Li, Y.
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==See Also==
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*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
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Description: A moderator XD22 binding to bile acid receptor
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Lu, Y]]
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__TOC__
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[[Category: Li, Y]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li Y]]
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[[Category: Lu Y]]

Current revision

A moderator XD22 binding to bile acid receptor

PDB ID 5y49

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