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2z95

From Proteopedia

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[[Image:2z95.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of GDP-D-Mannose Dehydratase from Aquifex aeolicus VF5==
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|PDB= 2z95 |SIZE=350|CAPTION= <scene name='initialview01'>2z95</scene>, resolution 2.60&Aring;
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<StructureSection load='2z95' size='340' side='right'caption='[[2z95]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Residue+A+1001'>AC1</scene> and <scene name='pdbsite=AC2:Gdp+Binding+Site+For+Residue+D+1002'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
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<table><tr><td colspan='2'>[[2z95]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z95 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/GDP-mannose_4,6-dehydratase GDP-mannose 4,6-dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.47 4.2.1.47] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE= rfbD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z95 OCA], [https://pdbe.org/2z95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z95 RCSB], [https://www.ebi.ac.uk/pdbsum/2z95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z95 ProSAT], [https://www.topsan.org/Proteins/RSGI/2z95 TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z95 OCA], [http://www.ebi.ac.uk/pdbsum/2z95 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z95 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/O67175_AQUAE O67175_AQUAE] Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (By similarity).[HAMAP-Rule:MF_00955]
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== Evolutionary Conservation ==
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'''Crystal Structure of GDP-D-Mannose Dehydratase from Aquifex aeolicus VF5'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/2z95_consurf.spt"</scriptWhenChecked>
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2Z95 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z95 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Aquifex aeolicus]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: GDP-mannose 4,6-dehydratase]]
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</jmolCheckbox>
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[[Category: Single protein]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z95 ConSurf].
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[[Category: Kuramitsu, S.]]
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<div style="clear:both"></div>
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[[Category: Niwa, H.]]
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__TOC__
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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</StructureSection>
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[[Category: Yokoyama, S.]]
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[[Category: Aquifex aeolicus VF5]]
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[[Category: lyase]]
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[[Category: Large Structures]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: Kuramitsu S]]
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[[Category: nppsfa]]
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[[Category: Niwa H]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Yokoyama S]]
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[[Category: rsgi]]
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[[Category: short-chain dehydrogenase/reductase]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:33 2008''
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Current revision

Crystal Structure of GDP-D-Mannose Dehydratase from Aquifex aeolicus VF5

PDB ID 2z95

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