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6n7x
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==S. cerevisiae U1 snRNP== | |
| + | <SX load='6n7x' size='340' side='right' viewer='molstar' caption='[[6n7x]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n7x]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5uz5 5uz5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N7X FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n7x OCA], [https://pdbe.org/6n7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n7x RCSB], [https://www.ebi.ac.uk/pdbsum/6n7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n7x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RU1C_YEAST RU1C_YEAST] Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.<ref>PMID:10072386</ref> <ref>PMID:12214237</ref> <ref>PMID:9233817</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Espinosa S]] | ||
| + | [[Category: Hansen KC]] | ||
| + | [[Category: Hill RC]] | ||
| + | [[Category: Jiang J]] | ||
| + | [[Category: Li X]] | ||
| + | [[Category: Liu S]] | ||
| + | [[Category: Zhang L]] | ||
| + | [[Category: Zhao R]] | ||
| + | [[Category: Zhou ZH]] | ||
Current revision
S. cerevisiae U1 snRNP
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Categories: Large Structures | Saccharomyces cerevisiae S288C | Espinosa S | Hansen KC | Hill RC | Jiang J | Li X | Liu S | Zhang L | Zhao R | Zhou ZH
