6n8n
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6n8n is ON HOLD Authors: Zhou, Y., Musalgaonkar, S., Johnson, A.W., Taylor, D.W. Description: Cryo-EM structure of Lsg1-engaged (LE) pre-60S riboso...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit== | |
| + | <SX load='6n8n' size='340' side='right' viewer='molstar' caption='[[6n8n]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n8n]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N8N FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n8n OCA], [https://pdbe.org/6n8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n8n RCSB], [https://www.ebi.ac.uk/pdbsum/6n8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n8n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RL15A_YEAST RL15A_YEAST] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The catalytic activity of the ribosome is mediated by RNA, yet proteins are essential for the function of the peptidyl transferase center (PTC). In eukaryotes, final assembly of the PTC occurs in the cytoplasm by insertion of the ribosomal protein Rpl10 (uL16). We determine structures of six intermediates in late nuclear and cytoplasmic maturation of the large subunit that reveal a tightly-choreographed sequence of protein and RNA rearrangements controlling the insertion of Rpl10. We also determine the structure of the biogenesis factor Yvh1 and show how it promotes assembly of the P stalk, a critical element for recruitment of GTPases that drive translation. Together, our structures provide a blueprint for final assembly of a functional ribosome. | ||
| - | + | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome.,Zhou Y, Musalgaonkar S, Johnson AW, Taylor DW Nat Commun. 2019 Feb 27;10(1):958. doi: 10.1038/s41467-019-08880-0. PMID:30814529<ref>PMID:30814529</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6n8n" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: Musalgaonkar | + | ==See Also== |
| - | [[Category: Zhou | + | *[[Ribosome 3D structures|Ribosome 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Johnson AW]] | ||
| + | [[Category: Musalgaonkar S]] | ||
| + | [[Category: Taylor DW]] | ||
| + | [[Category: Zhou Y]] | ||
Current revision
Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit
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