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5jud

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Current revision (19:07, 20 September 2023) (edit) (undo)
 
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==Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis in complex with uridine-diphosphate (UDP) - GpgS*UDP==
==Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis in complex with uridine-diphosphate (UDP) - GpgS*UDP==
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<StructureSection load='5jud' size='340' side='right' caption='[[5jud]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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<StructureSection load='5jud' size='340' side='right'caption='[[5jud]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycbo Mycbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JUD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_variant_bovis_AF2122/97 Mycobacterium tuberculosis variant bovis AF2122/97]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JUD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5juc|5juc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gpgS, Mb1240 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=233413 MYCBO])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jud OCA], [https://pdbe.org/5jud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jud RCSB], [https://www.ebi.ac.uk/pdbsum/5jud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jud ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosyl-3-phosphoglycerate_synthase Glucosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.266 2.4.1.266] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jud OCA], [http://pdbe.org/5jud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jud RCSB], [http://www.ebi.ac.uk/pdbsum/5jud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jud ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GPGS_MYCBO GPGS_MYCBO]] Involved in the biosynthesis of methylglucose lipopolysaccharides (MGLPs). Catalyzes the condensation of NDP-glucose and 3-phospho-glycerate (3-PGA) to yield glucosyl-3-phosphoglycerate (GPG). It can use UDP-glucose, ADP-glucose and GDP-glucose as donor substrates with decreasing affinity, and 3-PGA as an acceptor. D-glycerate could only be the acceptor with ADP-glucose and at a very low rate.<ref>PMID:18221489</ref>
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[https://www.uniprot.org/uniprot/GPGS_MYCBO GPGS_MYCBO] Involved in the biosynthesis of methylglucose lipopolysaccharides (MGLPs). Catalyzes the condensation of NDP-glucose and 3-phospho-glycerate (3-PGA) to yield glucosyl-3-phosphoglycerate (GPG). It can use UDP-glucose, ADP-glucose and GDP-glucose as donor substrates with decreasing affinity, and 3-PGA as an acceptor. D-glycerate could only be the acceptor with ADP-glucose and at a very low rate.<ref>PMID:18221489</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glucosyl-3-phosphoglycerate synthase]]
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[[Category: Large Structures]]
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[[Category: Mycbo]]
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[[Category: Mycobacterium tuberculosis variant bovis AF2122/97]]
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[[Category: Albesa-Jove, D]]
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[[Category: Albesa-Jove D]]
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[[Category: Arrasate, P]]
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[[Category: Arrasate P]]
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[[Category: Carreras-Gonzalez, A]]
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[[Category: Carreras-Gonzalez A]]
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[[Category: Comino, N]]
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[[Category: Comino N]]
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[[Category: Guerin, M E]]
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[[Category: Guerin ME]]
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[[Category: Rodrigo-Unzueta, A]]
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[[Category: Rodrigo-Unzueta A]]
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[[Category: Sancho-Vaello, E]]
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[[Category: Sancho-Vaello E]]
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[[Category: Urresti, S]]
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[[Category: Urresti S]]
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[[Category: Transferase]]
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Current revision

Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis in complex with uridine-diphosphate (UDP) - GpgS*UDP

PDB ID 5jud

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