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3fbk

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==Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A==
==Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A==
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<StructureSection load='3fbk' size='340' side='right' caption='[[3fbk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3fbk' size='340' side='right'caption='[[3fbk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fbk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FBK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fbk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FBK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbk OCA], [https://pdbe.org/3fbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fbk RCSB], [https://www.ebi.ac.uk/pdbsum/3fbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fbk ProSAT], [https://www.topsan.org/Proteins/NESGC/3fbk TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbk OCA], [http://pdbe.org/3fbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fbk RCSB], [http://www.ebi.ac.uk/pdbsum/3fbk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fbk ProSAT], [http://www.topsan.org/Proteins/NESGC/3fbk TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN]] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref>
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[https://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref>
==See Also==
==See Also==
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*[[Regulator of G protein signaling|Regulator of G protein signaling]]
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Acton, T B]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C]]
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[[Category: Acton TB]]
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[[Category: Everett, J K]]
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[[Category: Ciccosanti C]]
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[[Category: Foote, E L]]
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[[Category: Everett JK]]
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[[Category: Forouhar, F]]
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[[Category: Foote EL]]
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[[Category: Hunt, J F]]
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[[Category: Forouhar F]]
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[[Category: Lew, S]]
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[[Category: Hunt JF]]
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[[Category: Mao, L]]
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[[Category: Lew S]]
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[[Category: Montelione, G T]]
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[[Category: Mao L]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Nair, R]]
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[[Category: Nair R]]
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[[Category: Rost, B]]
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[[Category: Rost B]]
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[[Category: Seetharaman, J]]
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[[Category: Seetharaman J]]
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[[Category: Shastry, R]]
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[[Category: Shastry R]]
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[[Category: Tong, L]]
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[[Category: Tong L]]
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[[Category: Xiao, R]]
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[[Category: Xiao R]]
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[[Category: All beta-sheet fold]]
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[[Category: Alternative splicing]]
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[[Category: Cell membrane]]
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[[Category: Cytoplasm]]
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[[Category: Membrane]]
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[[Category: Nesg]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Signal transduction inhibitor]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A

PDB ID 3fbk

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