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3fb1

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==Crystal Structure of Purine Nucleoside Phosphorylase in Complex with Ribose-1-Phosphate==
==Crystal Structure of Purine Nucleoside Phosphorylase in Complex with Ribose-1-Phosphate==
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<StructureSection load='3fb1' size='340' side='right' caption='[[3fb1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3fb1' size='340' side='right'caption='[[3fb1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fb1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FB1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fb1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FB1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=R1P:RIBOSE-1-PHOSPHATE'>R1P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.002&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1td1|1td1]], [[1tcu|1tcu]], [[1tcv|1tcv]], [[3f8w|3f8w]], [[3faz|3faz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=R1P:RIBOSE-1-PHOSPHATE'>R1P</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SmPNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb1 OCA], [https://pdbe.org/3fb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb1 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb1 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb1 OCA], [http://pdbe.org/3fb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fb1 RCSB], [http://www.ebi.ac.uk/pdbsum/3fb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb1 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q9BMI9_SCHMA Q9BMI9_SCHMA]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity).[PIRNR:PIRNR000477]
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[https://www.uniprot.org/uniprot/Q9BMI9_SCHMA Q9BMI9_SCHMA] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity).[PIRNR:PIRNR000477]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Purine nucleoside phosphorylase|Purine nucleoside phosphorylase]]
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*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Blood fluke]]
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[[Category: Large Structures]]
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[[Category: Purine-nucleoside phosphorylase]]
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[[Category: Schistosoma mansoni]]
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[[Category: Garratt, R C]]
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[[Category: Garratt RC]]
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[[Category: Oliva, G]]
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[[Category: Oliva G]]
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[[Category: Pereira, H M]]
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[[Category: Pereira HM]]
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[[Category: Glycosyltransferase]]
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[[Category: Purine nucleoside phsophorylase]]
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[[Category: Ribose-1-phosphate]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Purine Nucleoside Phosphorylase in Complex with Ribose-1-Phosphate

PDB ID 3fb1

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