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| - | [[Image:399d.gif|left|200px]] | |
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| - | {{Structure
| + | ==STRUCTURE OF D(CGCCCGCGGGCG)== |
| - | |PDB= 399d |SIZE=350|CAPTION= <scene name='initialview01'>399d</scene>, resolution 1.9Å
| + | <StructureSection load='399d' size='340' side='right'caption='[[399d]], [[Resolution|resolution]] 1.90Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>
| + | <table><tr><td colspan='2'>[[399d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=399D FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | |GENE=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=399d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=399d OCA], [https://pdbe.org/399d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=399d RCSB], [https://www.ebi.ac.uk/pdbsum/399d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=399d ProSAT]</span></td></tr> |
| - | |DOMAIN=
| + | </table> |
| - | |RELATEDENTRY=
| + | __TOC__ |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=399d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=399d OCA], [http://www.ebi.ac.uk/pdbsum/399d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=399d RCSB]</span>
| + | </StructureSection> |
| - | }}
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Synthetic construct]] |
| - | '''STRUCTURE OF D(CGCCCGCGGGCG)'''
| + | [[Category: Fernandez LG]] |
| - | | + | [[Category: Malinina L]] |
| - | | + | [[Category: Subirana JA]] |
| - | ==Overview==
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| - | We have determined the structure of the dodecamer duplex d(CGCCCGCGGGCG)2. A careful use of the molecular replacement programme AMoRe has been essential in order to solve the structure. This dodecamer shows a unique conformation, quite different from all the previously studied oligonucleotide duplexes: the central octamer has an A conformation, but with a sharp 65 degrees kink in the centre; the terminal base-steps have a B-like conformation; the major groove is completely closed in the centre, a hollow molecule is thus found. The results obtained confirm the high degree of variability of DNA structure. A new type of kink and an intermediate A/B double-helical conformation have been found. Such intermediate conformation differs from those described in DNA polymerase complexes.
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| - | | + | |
| - | ==About this Structure==
| + | |
| - | 399D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA].
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| - | ==Reference==
| + | |
| - | Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9917405 9917405]
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| - | [[Category: Protein complex]] | + | |
| - | [[Category: Fernandez, L G.]] | + | |
| - | [[Category: Malinina, J A.Subirana L.]] | + | |
| - | [[Category: double helix]] | + | |
| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:22:10 2008''
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