3guu

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==X-ray structure of Candida Antarctica lipase A==
==X-ray structure of Candida Antarctica lipase A==
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<StructureSection load='3guu' size='340' side='right' caption='[[3guu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3guu' size='340' side='right'caption='[[3guu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3guu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_antarctica Candida antarctica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GUU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3guu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moesziomyces_antarcticus Moesziomyces antarcticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GUU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3guu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3guu OCA], [http://pdbe.org/3guu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3guu RCSB], [http://www.ebi.ac.uk/pdbsum/3guu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3guu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3guu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3guu OCA], [https://pdbe.org/3guu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3guu RCSB], [https://www.ebi.ac.uk/pdbsum/3guu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3guu ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LIPA_MOEAP LIPA_MOEAP] Hydrolyzes triglycerides, with a preference for substrates with short-chain lengths (C4 to C8). Has the highest activity with tributyrin (C4), followed by tricaproin (C6) and tricaprylin (C8). Can also hydrolyze vinylacetate (C2) and triolein (C18), but with lower efficiency. Has no activity with tripalmitin (C16).<ref>PMID:16575565</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/3guu_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/3guu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Lipase|Lipase]]
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*[[Lipase 3D Structures|Lipase 3D Structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Candida antarctica]]
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[[Category: Large Structures]]
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[[Category: Triacylglycerol lipase]]
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[[Category: Moesziomyces antarcticus]]
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[[Category: Airenne, T]]
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[[Category: Airenne T]]
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[[Category: Brandt, A M]]
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[[Category: Brandt A-M]]
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[[Category: Kanerva, L T]]
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[[Category: Kanerva LT]]
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[[Category: Li, X G]]
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[[Category: Li X-G]]
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[[Category: Nymalm-Rejstrom, Y]]
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[[Category: Nymalm-Rejstrom Y]]
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[[Category: Salminen, T A]]
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[[Category: Salminen TA]]
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[[Category: Candida]]
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[[Category: Hydrolase]]
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[[Category: Lipase]]
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[[Category: Protein structure]]
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Current revision

X-ray structure of Candida Antarctica lipase A

PDB ID 3guu

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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