3gz1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (03:52, 6 June 2025) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal structure of IpgC in complex with the chaperone binding region of IpaB==
==Crystal structure of IpgC in complex with the chaperone binding region of IpaB==
-
<StructureSection load='3gz1' size='340' side='right' caption='[[3gz1]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+
<StructureSection load='3gz1' size='340' side='right'caption='[[3gz1]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3gz1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GZ1 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3gz1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GZ1 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gyz|3gyz]], [[3gz2|3gz2]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ipgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gz1 OCA], [https://pdbe.org/3gz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gz1 RCSB], [https://www.ebi.ac.uk/pdbsum/3gz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gz1 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gz1 OCA], [http://pdbe.org/3gz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gz1 RCSB], [http://www.ebi.ac.uk/pdbsum/3gz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gz1 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/IPGC_SHIFL IPGC_SHIFL]] Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG. [[http://www.uniprot.org/uniprot/IPAB_SHIFL IPAB_SHIFL]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Forms a pore with IpaC, which is inserted into the host cell membrane through the Mxi/Spa apparatus, during cell contact. This pore probably allows the translocation of IpaA. IpaB has also been found to be necessary and sufficient to activate macrophage apoptosis by binding to interleukin-1 beta converting enzyme (ICE). Has also been shown to be important, along with IpaD, to block or regulate secretion through the Mxi/Spa translocon in the presence or absence of the secretion signal, respectively. Through interaction with host human MAD2L2, constitutively activates the anaphase-promoting complex APC and induces a cell cycle arrest to prevent epithelial renewal in order to promote bacterial colonization.<ref>PMID:17719540</ref> <ref>PMID:9009343</ref>
+
[https://www.uniprot.org/uniprot/IPGC_SHIFL IPGC_SHIFL] Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 16: Line 15:
<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/3gz1_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/3gz1_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
Line 34: Line 33:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Shigella paradysenteriae weldin 1927]]
+
[[Category: Large Structures]]
-
[[Category: Kolbe, M]]
+
[[Category: Shigella flexneri]]
-
[[Category: Lokareddy, R K]]
+
[[Category: Kolbe M]]
-
[[Category: Lunelli, M]]
+
[[Category: Lokareddy RK]]
-
[[Category: Zychlinsky, A]]
+
[[Category: Lunelli M]]
-
[[Category: Chaperone]]
+
[[Category: Zychlinsky A]]
-
[[Category: Chaperone binding region]]
+
-
[[Category: Membrane]]
+
-
[[Category: Secreted]]
+
-
[[Category: Tetratricopeptide repeat]]
+
-
[[Category: Tpr]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Virulence]]
+

Current revision

Crystal structure of IpgC in complex with the chaperone binding region of IpaB

PDB ID 3gz1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3gz1"
Personal tools