3gbg

<StructureSection load='3gbg' size='340' side='right' caption='[[3gbg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[3gbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibc3 Vibc3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBG FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tcpN, toxT, VC0395_A0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [http://pdbe.org/3gbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [http://www.ebi.ac.uk/pdbsum/3gbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbg ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/TCPN_VIBC3 TCPN_VIBC3]] Probable regulatory protein for the tcp operon.

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== Publication Abstract from PubMed ==

Cholera is an acute intestinal infection caused by the bacterium Vibrio cholerae. In order for V. cholerae to cause disease, it must produce two virulence factors, the toxin-coregulated pilus (TCP) and cholera toxin (CT), whose expression is controlled by a transcriptional cascade culminating with the expression of the AraC-family regulator, ToxT. We have solved the 1.9 A resolution crystal structure of ToxT, which reveals folds in the N- and C-terminal domains that share a number of features in common with AraC, MarA, and Rob as well as the unexpected presence of a buried 16-carbon fatty acid, cis-palmitoleate. The finding that cis-palmitoleic acid reduces TCP and CT expression in V. cholerae and prevents ToxT from binding to DNA in vitro provides a direct link between the host environment of V. cholerae and regulation of virulence gene expression.

Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes.,Lowden MJ, Skorupski K, Pellegrini M, Chiorazzo MG, Taylor RK, Kull FJ Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2860-5. Epub 2010 Feb 1. PMID:20133655<ref>PMID:20133655</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3gbg" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Vibc3]]

[[Category: Kull, F J]]

[[Category: Lowden, M J]]

[[Category: Activator]]

[[Category: Virulence]]