3gz2

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==Crystal structure of IpgC in complex with an IpaB peptide==
==Crystal structure of IpgC in complex with an IpaB peptide==
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<StructureSection load='3gz2' size='340' side='right' caption='[[3gz2]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='3gz2' size='340' side='right'caption='[[3gz2]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gz2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GZ2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gz2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GZ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gyz|3gyz]], [[3gz1|3gz1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ipgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927]), ipaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gz2 OCA], [https://pdbe.org/3gz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3gz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gz2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gz2 OCA], [http://pdbe.org/3gz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gz2 RCSB], [http://www.ebi.ac.uk/pdbsum/3gz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gz2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IPGC_SHIFL IPGC_SHIFL]] Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG. [[http://www.uniprot.org/uniprot/IPAB_SHIFL IPAB_SHIFL]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Forms a pore with IpaC, which is inserted into the host cell membrane through the Mxi/Spa apparatus, during cell contact. This pore probably allows the translocation of IpaA. IpaB has also been found to be necessary and sufficient to activate macrophage apoptosis by binding to interleukin-1 beta converting enzyme (ICE). Has also been shown to be important, along with IpaD, to block or regulate secretion through the Mxi/Spa translocon in the presence or absence of the secretion signal, respectively. Through interaction with host human MAD2L2, constitutively activates the anaphase-promoting complex APC and induces a cell cycle arrest to prevent epithelial renewal in order to promote bacterial colonization.<ref>PMID:17719540</ref> <ref>PMID:9009343</ref>
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[https://www.uniprot.org/uniprot/IPGC_SHIFL IPGC_SHIFL] Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Shigella paradysenteriae weldin 1927]]
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[[Category: Large Structures]]
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[[Category: Kolbe, M]]
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[[Category: Shigella flexneri]]
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[[Category: Lokareddy, R K]]
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[[Category: Kolbe M]]
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[[Category: Lunelli, M]]
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[[Category: Lokareddy RK]]
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[[Category: Chaperone]]
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[[Category: Lunelli M]]
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[[Category: Chaperone binding region]]
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[[Category: Secreted]]
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[[Category: Tetratricopeptide repeat]]
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[[Category: Tpr]]
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[[Category: Transmembrane]]
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[[Category: Virulence]]
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Current revision

Crystal structure of IpgC in complex with an IpaB peptide

PDB ID 3gz2

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