Syntaxin-binding protein

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<StructureSection load='3puj' size='340' side='right' caption='Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide (pink) (PDB code [[3puj]])' scene='80/803232/Cv/1'>
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<StructureSection load='3puj' size='340' side='right' caption='Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide (magenta) (PDB code [[3puj]])' scene='80/803232/Cv/1'>
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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<scene name='80/803232/Cv/3'>Syntaxin-binding protein 1 interaction with the N-terminal peptide of syntaxin-1</scene> which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions<ref name="stxbp"/>.
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<scene name='80/803232/Cv/4'>Syntaxin-binding protein 1 interaction with the N-terminal peptide of syntaxin-1</scene> which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions<ref name="stxbp"/>.
</StructureSection>
</StructureSection>
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*Syntaxin-binding protein 1 or Munc18-1
*Syntaxin-binding protein 1 or Munc18-1
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**[[4jeh]], [[4jeu]], [[3c98]] – rSTXBP1 + syntaxin 1a – rat<br />
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**[[6lpc]] – rSTXBP1 (mutant) – rat<br />
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**[[4jeh]], [[4jeu]], [[3c98]] – rSTXBP1 + STX-1a<br />
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**[[7udb]], [[7udc]] – rSTXBP1 + synaptobrevin-2 + STX-1a – Cryo EM<br />
**[[3puj]] – rSTXBP1 + syntaxin 4 peptide <br />
**[[3puj]] – rSTXBP1 + syntaxin 4 peptide <br />
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**[[7xsj]] – rSTXBP1 + Syntaxin 1a N-terminal+SNARE motif + amyloid-beta A4<br />
*Syntaxin-binding protein 2 or Munc18-2
*Syntaxin-binding protein 2 or Munc18-2

Current revision

Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide (magenta) (PDB code 3puj)

Drag the structure with the mouse to rotate

3D structures of syntaxin-binding protein

Updated on 11-December-2023

References

  1. ↑ 1.0 1.1 Hu SH, Christie MP, Saez NJ, Latham CF, Jarrott R, Lua LH, Collins BM, Martin JL. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A. 2010 Dec 30. PMID:21193638 doi:10.1073/pnas.0914906108

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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