6ic4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Cryo-EM structure of the A. baumannii MLA complex at 8.7 A resolution== |
| + | <SX load='6ic4' size='340' side='right' viewer='molstar' caption='[[6ic4]], [[Resolution|resolution]] 8.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ic4]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IC4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IC4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ttg2C, SAMEA104305283_00402 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA]), ttg2B, mlaE, A7M79_03105, A7M90_14775, A7N09_05510, Aba7804_03380, Aba810CP_02080, APD06_03860, AZE33_17930, B4R90_07005, B9X95_19830, BGC29_10505, C2U32_12245, C3415_18770, CAS83_02490, CHQ89_09020, CPI82_03200, DCD77_11945, IX87_12245, LV38_01098, SAMEA104305242_00211, SAMEA104305261_03368, SAMEA104305271_02119, SAMEA104305341_02652, SAMEA104305343_00596, SAMEA104305351_00191, SAMEA104305385_01589 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA]), ttg2A, A7M79_03110, A7M90_14770, A7N09_05505, AB719_19875, Aba810CP_02075, B4R90_07000, B9X91_22285, BGC29_10510, BWP00_03605, C3415_18775, C7G90_12995, CBE85_06065, CEJ63_09375, CPI82_03205, CSB70_3297, IX87_12250, NCTC13305_02842, SAMEA104305208_00091, SAMEA104305242_00212, SAMEA104305271_02118, SAMEA104305318_02181, SAMEA104305341_02651, SAMEA104305343_00597, SAMEA104305351_00192, SAMEA104305385_01588 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA]), SAMEA104305318_02185 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ic4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ic4 OCA], [http://pdbe.org/6ic4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ic4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ic4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ic4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The outer membrane (OM) of Gram-negative bacteria serves as a selective permeability barrier that allows entry of essential nutrients while excluding toxic compounds, including antibiotics. The OM is asymmetric and contains an outer leaflet of lipopolysaccharides (LPS) or lipooligosaccharides (LOS) and an inner leaflet of glycerophospholipids (GPL). We screened Acinetobacter baumannii transposon mutants and identified a number of mutants with OM defects, including an ABC transporter system homologous to the Mla system in E. coli. We further show that this opportunistic, antibiotic-resistant pathogen uses this multicomponent protein complex and ATP hydrolysis at the inner membrane to promote GPL export to the OM. The broad conservation of the Mla system in Gram-negative bacteria suggests the system may play a conserved role in OM biogenesis. The importance of the Mla system to Acinetobacter baumannii OM integrity and antibiotic sensitivity suggests that its components may serve as new antimicrobial therapeutic targets. | ||
| - | + | The Acinetobacter baumannii Mla system and glycerophospholipid transport to the outer membrane.,Kamischke C, Fan J, Bergeron J, Kulasekara HD, Dalebroux ZD, Burrell A, Kollman JM, Miller SI Elife. 2019 Jan 14;8. pii: 40171. doi: 10.7554/eLife.40171. PMID:30638443<ref>PMID:30638443</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6ic4" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Aciba]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bergeron, J R]] | ||
| + | [[Category: Kollman, J M]] | ||
| + | [[Category: Membrane protein antibiotic resistance abc transporter]] | ||
| + | [[Category: Protein transport]] | ||
Current revision
Cryo-EM structure of the A. baumannii MLA complex at 8.7 A resolution
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