6iw7
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6iw7 is ON HOLD Authors: Bao, R., Luo, Y.Z., Zhu, Y.B., Yang, Y., Zhou, Y.Z. Description: structural insights into Mycobacterium tuberculosis ClpP1...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease== | |
| - | + | <StructureSection load='6iw7' size='340' side='right'caption='[[6iw7]], [[Resolution|resolution]] 2.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6iw7]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IW7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.692121Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AV3:4-[(4-fluoro-2-methyl-3H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline'>AV3</scene>, <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iw7 OCA], [https://pdbe.org/6iw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iw7 RCSB], [https://www.ebi.ac.uk/pdbsum/6iw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iw7 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Luo | + | [https://www.uniprot.org/uniprot/CLPP2_MYCTU CLPP2_MYCTU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpX. Degrades anti-sigma-E factor RseA in the presence of ClpC1. Does not seem to act on anti-sigma-L factor RslA.[HAMAP-Rule:MF_00444]<ref>PMID:20025669</ref> <ref>PMID:23314154</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis CDC1551]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Bao R]] | ||
| + | [[Category: Luo YF]] | ||
| + | [[Category: Yang Y]] | ||
| + | [[Category: Zhou YZ]] | ||
| + | [[Category: Zhu YB]] | ||
Current revision
structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease
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