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6n14

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'''Unreleased structure'''
 
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The entry 6n14 is ON HOLD until Paper Publication
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==Phosphoserine BlaC, Class A serine beta-lactamase from Mycobacterium tuberculosis==
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<StructureSection load='6n14' size='340' side='right'caption='[[6n14]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6n14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N14 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5216947&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n14 OCA], [https://pdbe.org/6n14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n14 RCSB], [https://www.ebi.ac.uk/pdbsum/6n14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n14 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAC_MYCTU BLAC_MYCTU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mycobacterium tuberculosis, the pathogen responsible for tuberculosis (TB), is the leading cause of death from infectious disease worldwide. The class A serine beta-lactamase BlaC confers Mycobacterium tuberculosis resistance to conventional beta-lactam antibiotics. As the primary mechanism of bacterial resistance to beta-lactam antibiotics, the expression of a beta-lactamase by Mycobacterium tuberculosis results in hydrolysis of the beta-lactam ring and deactivation of these antibiotics. In this study, we conducted protein X-ray crystallographic analysis of the inactivation of BlaC, upon exposure to the inhibitor bis(benzoyl) phosphate. Crystal structure data confirms that serine beta-lactamase is phosphorylated at the catalytic serine residue (Ser-70) by this phosphate-based inactivator. This new crystallographic evidence suggests a mechanism for phosphorylation of BlaC inhibition by bis(benzoyl) phosphate over acylation. Additionally, we confirmed that bis(benzoyl) phosphate inactivated BlaC in a time-dependent manner.
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Authors: Moural, T.W., White, D.S., Choy, C.J., Kang, C., Berkman, C.E.
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Crystal Structure of Phosphoserine BlaC from Mycobacterium tuberculosis Inactivated by Bis(Benzoyl) Phosphate.,Moural TW, White DS, Choy CJ, Kang C, Berkman CE Int J Mol Sci. 2019 Jul 2;20(13). pii: ijms20133247. doi: 10.3390/ijms20133247. PMID:31269656<ref>PMID:31269656</ref>
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Description: Phosphoserine BlaC, Class A serine beta-lactamase from Mycobacterium tuberculosis
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Berkman, C.E]]
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<div class="pdbe-citations 6n14" style="background-color:#fffaf0;"></div>
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[[Category: Kang, C]]
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[[Category: White, D.S]]
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==See Also==
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[[Category: Moural, T.W]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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[[Category: Choy, C.J]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Berkman CE]]
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[[Category: Choy CJ]]
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[[Category: Kang C]]
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[[Category: Moural TW]]
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[[Category: White DS]]

Current revision

Phosphoserine BlaC, Class A serine beta-lactamase from Mycobacterium tuberculosis

PDB ID 6n14

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