6n44
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Sheep Galectin-11 (LGALS11) complex with glycerol== | |
| + | <StructureSection load='6n44' size='340' side='right'caption='[[6n44]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n44]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N44 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n44 OCA], [https://pdbe.org/6n44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n44 RCSB], [https://www.ebi.ac.uk/pdbsum/6n44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n44 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0A7EMW6_SHEEP A0A0A7EMW6_SHEEP] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Galectins are a family of glycan-binding molecules with a characteristic affinity for ss-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites. | ||
| - | + | The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries).,Sakthivel D, Preston S, Gasser RB, Costa TPSD, Hernandez JN, Shahine A, Shakif-Azam MD, Lock P, Rossjohn J, Perugini MA, Gonzalez JF, Meeusen E, Piedrafita D, Beddoe T Commun Biol. 2020 Aug 21;3(1):464. doi: 10.1038/s42003-020-01179-7. PMID:32826940<ref>PMID:32826940</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6n44" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Galectin 3D structures|Galectin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ovis aries]] | ||
| + | [[Category: Beddoe TC]] | ||
| + | [[Category: Sakthivel D]] | ||
Current revision
Sheep Galectin-11 (LGALS11) complex with glycerol
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