6nad
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Identification and biological evaluation of tertiary ALCOHOL-based inverse agonists of RORgt== | |
| - | + | <StructureSection load='6nad' size='340' side='right'caption='[[6nad]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6nad]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NAD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9019709Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KHY:(S)-(4-chloro-2-methoxy-3-{[4-(trifluoromethyl)piperidin-1-yl]methyl}quinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)[2-(trifluoromethyl)pyridin-4-yl]methanol'>KHY</scene></td></tr> |
| - | [[Category: Milligan | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nad OCA], [https://pdbe.org/6nad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nad RCSB], [https://www.ebi.ac.uk/pdbsum/6nad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nad ProSAT]</span></td></tr> |
| - | [[Category: Spurlino | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Milligan C]] | ||
| + | [[Category: Spurlino J]] | ||
Current revision
Identification and biological evaluation of tertiary ALCOHOL-based inverse agonists of RORgt
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