3bch

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[[Image:3bch.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of the Human Laminin Receptor Precursor==
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|PDB= 3bch |SIZE=350|CAPTION= <scene name='initialview01'>3bch</scene>, resolution 2.15&Aring;
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<StructureSection load='3bch' size='340' side='right'caption='[[3bch]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[3bch]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BCH FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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|GENE= RPSA, LAMBR, LAMR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bch OCA], [https://pdbe.org/3bch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bch RCSB], [https://www.ebi.ac.uk/pdbsum/3bch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bch ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bch OCA], [http://www.ebi.ac.uk/pdbsum/3bch PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bch RCSB]</span>
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[https://www.uniprot.org/uniprot/RSSA_HUMAN RSSA_HUMAN] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.<ref>PMID:6300843</ref> <ref>PMID:16263087</ref> <ref>PMID:15516338</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Crystal Structure of the Human Laminin Receptor Precursor'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/3bch_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases. LamR is overexpressed on tumor cells, and targeting LamR elicits anti-cancer effects. Here, we report the crystal structure of human LamR, which provides insights into its function and should facilitate the design of novel therapeutics targeting LamR.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bch ConSurf].
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3BCH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCH OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Crystal structure of the human laminin receptor precursor., Jamieson KV, Wu J, Hubbard SR, Meruelo D, J Biol Chem. 2008 Feb 8;283(6):3002-5. Epub 2007 Dec 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18063583 18063583]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hubbard, S R.]]
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[[Category: Hubbard SR]]
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[[Category: Jamieson, K V.]]
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[[Category: Jamieson KV]]
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[[Category: Meruelo, D.]]
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[[Category: Meruelo D]]
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[[Category: Wu, J.]]
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[[Category: Wu J]]
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[[Category: acetylation]]
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[[Category: cell adhesion]]
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[[Category: cytoplasm]]
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[[Category: laminin receptor]]
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[[Category: p40 ribosomal protein]]
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[[Category: phosphorylation]]
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[[Category: polymorphism]]
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[[Category: ribonucleoprotein]]
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[[Category: ribosomal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:11 2008''
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Current revision

Crystal Structure of the Human Laminin Receptor Precursor

PDB ID 3bch

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