6a22

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:14, 22 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T.==
==Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T.==
-
<StructureSection load='6a22' size='340' side='right' caption='[[6a22]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
+
<StructureSection load='6a22' size='340' side='right'caption='[[6a22]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6a22]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A22 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6a22]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A22 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9P6:2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide'>9P6</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a22 OCA], [http://pdbe.org/6a22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a22 RCSB], [http://www.ebi.ac.uk/pdbsum/6a22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a22 ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9P6:2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide'>9P6</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a22 OCA], [https://pdbe.org/6a22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a22 RCSB], [https://www.ebi.ac.uk/pdbsum/6a22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a22 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
+
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 6a22" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6a22" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adachi, T]]
+
[[Category: Homo sapiens]]
-
[[Category: Doi, S]]
+
[[Category: Large Structures]]
-
[[Category: Noguchi, M]]
+
[[Category: Adachi T]]
-
[[Category: Nomura, A]]
+
[[Category: Doi S]]
-
[[Category: Yamaguchi, K]]
+
[[Category: Noguchi M]]
-
[[Category: Nuclear protein]]
+
[[Category: Nomura A]]
-
[[Category: Nuclear protein-inhibitor complex]]
+
[[Category: Yamaguchi K]]
-
[[Category: Nuclear receptor]]
+
-
[[Category: Ternary complex]]
+

Current revision

Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T.

PDB ID 6a22

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6a22"
Personal tools