6aaf

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==Crystal structure of fission yeast Atg8 complexed with the helical AIM of Hfl1.==
==Crystal structure of fission yeast Atg8 complexed with the helical AIM of Hfl1.==
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<StructureSection load='6aaf' size='340' side='right' caption='[[6aaf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='6aaf' size='340' side='right'caption='[[6aaf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6aaf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AAF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6aaf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AAF FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aaf OCA], [http://pdbe.org/6aaf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aaf RCSB], [http://www.ebi.ac.uk/pdbsum/6aaf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aaf ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.197&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aaf OCA], [https://pdbe.org/6aaf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aaf RCSB], [https://www.ebi.ac.uk/pdbsum/6aaf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aaf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ATG8_SCHPO ATG8_SCHPO]] Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Contributes to the maintenance of cell viability under conditions of nitrogen-depletion. Plays a role in meiosis and sporulation and contributes to oxidative stress resistance (PubMed:17295836, PubMed:19778961, PubMed:20070859).[UniProtKB:P38182]<ref>PMID:17295836</ref> <ref>PMID:19778961</ref> <ref>PMID:20070859</ref>
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[https://www.uniprot.org/uniprot/ATG8_SCHPO ATG8_SCHPO] Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Contributes to the maintenance of cell viability under conditions of nitrogen-depletion. Plays a role in meiosis and sporulation and contributes to oxidative stress resistance (PubMed:17295836, PubMed:19778961, PubMed:20070859).[UniProtKB:P38182]<ref>PMID:17295836</ref> <ref>PMID:19778961</ref> <ref>PMID:20070859</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6aaf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6aaf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Noda, N N]]
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[[Category: Large Structures]]
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[[Category: Yamasaki, A]]
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Autophagy]]
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[[Category: Noda NN]]
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[[Category: Membrane protein]]
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[[Category: Yamasaki A]]
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[[Category: Vacuole]]
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Current revision

Crystal structure of fission yeast Atg8 complexed with the helical AIM of Hfl1.

PDB ID 6aaf

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