3bdq

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[[Image:3bdq.jpg|left|200px]]
 
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{{Structure
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==Room Tempreture Crystal Structure of Sterol Carrier Protein-2 Like-2==
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|PDB= 3bdq |SIZE=350|CAPTION= <scene name='initialview01'>3bdq</scene>, resolution 2.000&Aring;
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<StructureSection load='3bdq' size='340' side='right'caption='[[3bdq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>
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<table><tr><td colspan='2'>[[3bdq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BDQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bdq OCA], [https://pdbe.org/3bdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bdq RCSB], [https://www.ebi.ac.uk/pdbsum/3bdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bdq ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2qzt|2QZT]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bdq OCA], [http://www.ebi.ac.uk/pdbsum/3bdq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bdq RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q0GY13_AEDAE Q0GY13_AEDAE]
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== Evolutionary Conservation ==
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'''Room Tempreture Crystal Structure of Sterol Carrier Protein-2 Like-2'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/3bdq_consurf.spt"</scriptWhenChecked>
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Mosquito sterol carrier protein-2 (AeSCP-2) and sterol carrier protein-2-like2 (AeSCP-2L2) are members of the SCP-2 protein family with similar expression profiles in the mosquito life cycle. In an effort to understand how lipids can be transported by different SCP-2 proteins, the three-dimensional crystal structure of AeSCP-2L2 was solved at 1.7 A resolution. AeSCP-2L2 forms a dimer and binds three fatty acids, one of which resides in a position within the internal cavity at a right angle to the others. This first report of ligand-bound dimerized protein in the SCP-2 protein family indicates that the family has a much more divergent mode of interaction with ligands than previously reported. The potential function of AeSCP-2L2 was investigated via in vivo incorporation of [(3)H]cholesterol and [(3)H]palmitic acid. Overexpression of AeSCP-2L2 in mosquito cells leads to an increased uptake of free fatty acid, whereas knockdown of AeSCP-2L2 in adult females decreases the accumulation of free fatty acid in the fat body from a blood meal. In contrast, overexpression or knockdown of AeSCP-2L2 has no effect on cholesterol uptake. Our results suggest that the main function of AeSCP-2L2 is as a general intracellular fatty acid carrier, as opposed to having a dedicated role in cholesterol transport.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3BDQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BDQ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bdq ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Three-dimensional structure/function analysis of SCP-2-like2 reveals differences among SCP-2 family members., Dyer DH, Wessely V, Forest KT, Lan Q, J Lipid Res. 2008 Mar;49(3):644-53. Epub 2007 Dec 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18084051 18084051]
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</StructureSection>
[[Category: Aedes aegypti]]
[[Category: Aedes aegypti]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dyer, D H.]]
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[[Category: Dyer DH]]
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[[Category: Forest, K T.]]
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[[Category: Forest KT]]
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[[Category: Lan, Q.]]
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[[Category: Lan Q]]
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[[Category: alpha/beta protein]]
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[[Category: lipid carrier]]
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[[Category: lipid transport]]
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[[Category: sterol carrier protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:21 2008''
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Current revision

Room Tempreture Crystal Structure of Sterol Carrier Protein-2 Like-2

PDB ID 3bdq

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