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3hy3

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==Structure of human MTHFS with 10-formyltetrahydrofolate==
==Structure of human MTHFS with 10-formyltetrahydrofolate==
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<StructureSection load='3hy3' size='340' side='right' caption='[[3hy3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3hy3' size='340' side='right'caption='[[3hy3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hy3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HY3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hy3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HY3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10F:N-({4-[{[(2R,4S,4AR,6S,8AS)-2-AMINO-4-HYDROXYDECAHYDROPTERIDIN-6-YL]METHYL}(FORMYL)AMINO]PHENYL}CARBONYL)-D-GLUTAMIC+ACID'>10F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hxt|3hxt]], [[3hy4|3hy4]], [[3hy6|3hy6]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10F:N-({4-[{[(2R,4S,4AR,6S,8AS)-2-AMINO-4-HYDROXYDECAHYDROPTERIDIN-6-YL]METHYL}(FORMYL)AMINO]PHENYL}CARBONYL)-D-GLUTAMIC+ACID'>10F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTHFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hy3 OCA], [https://pdbe.org/3hy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hy3 RCSB], [https://www.ebi.ac.uk/pdbsum/3hy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hy3 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-formyltetrahydrofolate_cyclo-ligase 5-formyltetrahydrofolate cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.2 6.3.3.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hy3 OCA], [http://pdbe.org/3hy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hy3 RCSB], [http://www.ebi.ac.uk/pdbsum/3hy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hy3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MTHFS_HUMAN MTHFS_HUMAN]] Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
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[https://www.uniprot.org/uniprot/MTHFS_HUMAN MTHFS_HUMAN] Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5-formyltetrahydrofolate cyclo-ligase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Cheng, C]]
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[[Category: Cheng C]]
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[[Category: Li, Y]]
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[[Category: Li Y]]
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[[Category: Liu, Z J]]
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[[Category: Liu Z-J]]
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[[Category: Shaw, N]]
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[[Category: Shaw N]]
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[[Category: Song, G]]
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[[Category: Song G]]
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[[Category: Wu, D]]
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[[Category: Wu D]]
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[[Category: 10-formyltetrahydrofolate]]
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[[Category: Antifolate]]
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[[Category: Atp-binding]]
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[[Category: Cancer]]
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[[Category: Folate-binding]]
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[[Category: Ligase]]
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[[Category: Magnesium]]
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[[Category: Nucleotide-binding]]
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Current revision

Structure of human MTHFS with 10-formyltetrahydrofolate

PDB ID 3hy3

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