This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3bgv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:08, 30 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3bgv.jpg|left|200px]]
 
-
{{Structure
+
==Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH==
-
|PDB= 3bgv |SIZE=350|CAPTION= <scene name='initialview01'>3bgv</scene>, resolution 2.30&Aring;
+
<StructureSection load='3bgv' size='340' side='right'caption='[[3bgv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
+
<table><tr><td colspan='2'>[[3bgv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGV FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(guanine-N(7)-)-methyltransferase mRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.56 2.1.1.56] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
|GENE= RNMT, KIAA0398 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgv OCA], [https://pdbe.org/3bgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgv RCSB], [https://www.ebi.ac.uk/pdbsum/3bgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgv ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgv OCA], [http://www.ebi.ac.uk/pdbsum/3bgv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bgv RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref>
-
 
+
== Evolutionary Conservation ==
-
'''The crystals structure of mRNA cap guanine-N7 methyltransferase'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgv_consurf.spt"</scriptWhenChecked>
-
3BGV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGV OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgv ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: mRNA (guanine-N(7)-)-methyltransferase]]
+
[[Category: Antoshenko T]]
-
[[Category: Antoshenko, T.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Bochkarev A]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Lunin VV]]
-
[[Category: Lunin, V V.]]
+
[[Category: MacKenzie F]]
-
[[Category: MacKenzie, F.]]
+
[[Category: Min J]]
-
[[Category: Min, J.]]
+
[[Category: Plotnikov AN]]
-
[[Category: Plotnikov, A N.]]
+
[[Category: Weigelt J]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Wu H]]
-
[[Category: Weigelt, J.]]
+
[[Category: Zeng H]]
-
[[Category: Wu, H.]]
+
-
[[Category: Zeng, H.]]
+
-
[[Category: alternative splicing]]
+
-
[[Category: methyltransferase]]
+
-
[[Category: mrna capping]]
+
-
[[Category: mrna processing]]
+
-
[[Category: nucleus]]
+
-
[[Category: phosphoprotein]]
+
-
[[Category: rna-binding]]
+
-
[[Category: s-adenosyl-l-methionine]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomic]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:26:09 2008''
+

Current revision

Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH

PDB ID 3bgv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bgv"
Personal tools